Reactome | phospho-TBK1 [cytosol]

phospho-TBK1 [cytosol]

Stable Identifier

R-GGA-168379

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

p-S172-TBK1, E1C581

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Innate Immune System (Gallus gallus)
  - Toll-like Receptor Cascades (Gallus gallus)
    - Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
      - MyD88-independent TLR4 cascade (Gallus gallus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
        
        Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Gallus gallus)
        
        IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Gallus gallus)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Gallus gallus)
        
        p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Gallus gallus)
        
        phospho-TBK1 [cytosol] (Gallus gallus)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Gallus gallus)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Gallus gallus)
        
        p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Gallus gallus)
        
        phospho-TBK1 [cytosol] (Gallus gallus)
        
        Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Gallus gallus)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Gallus gallus)
        
        p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Gallus gallus)
        
        phospho-TBK1 [cytosol] (Gallus gallus)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE:IRF3/IRF7 [endosome membrane] (Gallus gallus)
        
        activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKBKE [endosome membrane] (Gallus gallus)
        
        p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Gallus gallus)
        
        phospho-TBK1 [cytosol] (Gallus gallus)
        
        TBK1 is phosphorylated within the activated TLR4 complex (Gallus gallus)
        
        p-S172-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Gallus gallus)
        
        phospho-TBK1 [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Death Receptor Signaling (Gallus gallus)
  - TNF signaling (Gallus gallus)
    - Regulation of TNFR1 signaling (Gallus gallus)
      - TBK1, IKBKE phosphorylate RIPK1 at T189 (Gallus gallus)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Gallus gallus)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Gallus gallus)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Gallus gallus)
        
        phospho-TBK1 [cytosol] (Gallus gallus)
        
        TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Gallus gallus)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Gallus gallus)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Gallus gallus)
        
        phospho-TBK1 [cytosol] (Gallus gallus)
        
        p-S-TBK1:p-S-TBK1, p-S-IKBKE:p-S-IKBKE [cytosol] (Gallus gallus)
        
        p-S172-TBK1:p-S172-TBK1 [cytosol] (Gallus gallus)
        
        phospho-TBK1 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:E1C581

Gene Names

TBK1

Reference Genes

BioGPS Gene:417825 TBK1

ENSEMBL:ENSGALG00000009840

ENSEMBL:ENSGALG00010013089.1 TBK1

Monarch:417825 TBK1

NCBI Gene:417825 TBK1

Reference Transcript

Other Identifiers

417825

GO:0000166

GO:0002218

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0005524

GO:0005575

GO:0005737

GO:0006468

GO:0010629

GO:0016740

GO:0032728

GO:0036211

GO:0050830

GO:0051219

GO:0098542

GO:0140096

GT_A_87_P016320

GT_A_87_P163742

Gga.10010.1.S1_at

GgaAffx.6169.1.S1_at

Participates

as a component of

Other forms of this molecule

phospho-TBK1 [cytosol]

TBK1 [cytosol]

Inferred From

p-S172-TBK1 [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 172 (in Homo sapiens)

Coordinate

172

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_015137058.1, XP_015137046.1, XP_015137053.1

OpenTargets

ENSG00000183735

Ensembl

ENSGALG00010013089, ENSGALT00010031383, ENSGALP00010018311

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