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phospho-MyrG-p-Y419-SRC [plasma membrane]
Stable Identifier
R-GGA-1810408
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
plasma membrane
Synonyms
P00523
Locations in the PathwayBrowser
Expand all
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
Netrin-1 signaling (Gallus gallus)
DCC mediated attractive signaling (Gallus gallus)
Phosphorylation of DCC by Fyn (Gallus gallus)
NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Gallus gallus)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Gallus gallus)
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional regulation by RUNX3 (Gallus gallus)
Regulation of RUNX3 expression and activity (Gallus gallus)
RUNX3 binds SRC (Gallus gallus)
MyrG-p-Y419-SRC:RUNX3 [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
RUNX3 translocates to the nucleus (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
SRC phosphorylates RUNX3 (Gallus gallus)
MyrG-p-Y419-SRC:RUNX3 [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Gallus gallus)
Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Recruitment of GRB2 to p-PTK2 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Translocation of PTK2 to Focal complexes (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Recruitment of BCAR1 to PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Autophosphorylation of SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Gallus gallus)
Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Recruitment of GRB2 to p-PTK2 (Gallus gallus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Phosphorylation of pPTK2 by SRC (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
SYK activation by SRC (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
SYK binds to integrin alphaIIb beta3 (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Translocation of PTK2 to Focal complexes (Gallus gallus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
Crk binding to p130cas (Gallus gallus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Recruitment of BCAR1 to PTK2 complex (Gallus gallus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Gallus gallus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Gallus gallus)
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
MAPK family signaling cascades (Gallus gallus)
MAPK1/MAPK3 signaling (Gallus gallus)
RAF/MAP kinase cascade (Gallus gallus)
RAF activation (Gallus gallus)
Phosphorylation of RAF (Gallus gallus)
RAF activating kinases [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
ESR-associated SRC autophosphorylates (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
PI3K binds membrane-associated estrogen receptors (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
PTK2 is recruited to methylated ESR1 (Gallus gallus)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Gallus gallus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ERBB2 (Gallus gallus)
SRC family kinases phosphorylate ERBB2 (Gallus gallus)
p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Signaling by ERBB4 (Gallus gallus)
Downregulation of ERBB4 signaling (Gallus gallus)
ERBB4s80 binds to SRC (Gallus gallus)
ERBB4s80:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Nuclear signaling by ERBB4 (Gallus gallus)
Translocation of ERBB4s80 to the nucleus (Gallus gallus)
ERBB4s80:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Signaling by MET (Gallus gallus)
MET promotes cell motility (Gallus gallus)
MET activates PTK2 signaling (Gallus gallus)
MET phosphorylates PTK2 (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
SRC phosphorylates PTK2 (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
p-Y397-PTK2 binds SRC (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Signaling by NTRKs (Gallus gallus)
Signaling by NTRK3 (TRKC) (Gallus gallus)
Activated NTRK3 signals through PI3K (Gallus gallus)
Activated NTRK3 promotes SRC autophosphorylation (Gallus gallus)
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
Signaling by PDGF (Gallus gallus)
Downstream signal transduction (Gallus gallus)
Activation of Src (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
phospho-MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
External Reference Information
External Reference
UniProt:P00523 SRC
Gene Names
SRC
Chain
initiator methionine:, chain:2-533
Reference Genes
BioGPS Gene:396442 SRC
KEGG:gga:396442 SRC
Monarch:396442 SRC
NCBI Gene:396442 SRC
UCSC:P00523 SRC
Reference Transcript
RefSeq:NM_205457.2 SRC
RefSeq:XM_015296348.1 SRC
Participates
as a component of
Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:p-Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
MyrG-p-Y419-SRC:RUNX3 [plasma membrane] (Gallus gallus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
NTF3:p-5Y-NTRK3 homodimer:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
ERBB4s80:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419-SRC [plasma membrane] (Gallus gallus)
as an input of
p-Y397-PTK2 binds SRC (Gallus gallus)
RUNX3 binds SRC (Gallus gallus)
ERBB4s80 binds to SRC (Gallus gallus)
as an output of
SRC phosphorylates RUNX3 (Gallus gallus)
as a member of
MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Gallus gallus)
p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane] (Gallus gallus)
as a candidate of
RAF activating kinases [plasma membrane] (Gallus gallus)
This entity regulates
Negatively
RUNX3 translocates to the nucleus
(Gallus gallus)
Other forms of this molecule
SRC-2 [cytosol]
SRC-1 [plasma membrane]
phospho-MyrG,p-Y530-SRC [plasma membrane]
phospho-p-Y419-SRC [cytosol]
MyrG-SRC [plasma membrane]
Src [cytosol]
phospho-p-Y419-SRC [cytosol]
SRC [cytosol]
Inferred From
MyrG-p-Y419-SRC [plasma membrane]
(Homo sapiens)
Modified Residues
Name
N-myristoylglycine at 2 (in Homo sapiens)
Coordinate
2
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Name
O4'-phospho-L-tyrosine at 419 (in Homo sapiens)
Coordinate
419
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_015151834.1
,
NP_990788.2
ZINC - Investigational
SRC_CHICK
ZINC - World Drugs
SRC_CHICK
ZINC - FDA approved
SRC_CHICK
ZINC - Substances
SRC_CHICK
ZINC target
P00523
PRO
P00523
ZINC - Predictions - Purchasable
SRC_CHICK
PDB
4HVV
,
1P13
,
2QLQ
,
7A3A
,
7A36
,
4JZ4
,
4RTY
,
3EL8
,
3OF0
,
3F3T
,
3FJ5
,
7A37
,
4AGW
,
6HVE
,
3D7U
,
2HWO
,
1PRL
,
5D11
,
3LOK
,
6XVO
,
1RLQ
,
3EN4
,
5XP5
,
7NES
,
3U51
,
3QLG
,
5K9I
,
6L8L
,
2OIQ
,
4OMM
,
7A31
,
7PW0
,
7PVY
,
3DQX
,
1F2F
,
2QQ7
,
4OMQ
,
7D57
,
7A35
,
7A34
,
7A39
,
3OEZ
,
7AH3
,
5TEH
,
3TZ7
,
4FIC
,
4YBK
,
6XX2
,
7A3D
,
6HVF
,
3F3U
,
4JZ3
,
2QI8
,
6XVN
,
4U5J
,
5SWH
,
1RLP
,
5T0P
,
3EN5
,
5XP7
,
3QLF
,
5OB1
,
4RTU
,
4LGH
,
5OAV
,
3G6H
,
4QT7
,
5SYS
,
4OMN
,
7PVZ
,
3GEQ
,
7A30
,
5I11
,
4RTW
,
7A33
,
4HVW
,
4YBJ
,
5J5S
,
4O2P
,
3TZ8
,
4LE9
,
7A3C
,
4RTZ
,
6WIW
,
2HWP
,
5EC7
,
3F3V
,
6XX5
,
3UQG
,
5D10
,
1NLP
,
3UQF
,
3F6X
,
3EN6
,
7NET
,
3TZ9
,
5OB0
,
4LGG
,
3SVV
,
7PVX
,
4OMO
,
2PTK
,
1SRM
,
4RTV
,
7A3B
,
4HVU
,
4OMP
,
3G5D
,
4MCV
,
3EL7
,
7A3E
,
3DQW
,
4RTX
,
7WF5
,
7A38
,
6XX3
,
3D7T
,
6XX4
,
3U4W
,
3F3W
,
5D12
,
1F1W
,
1PRM
,
5BMM
,
5ECA
,
6XVM
,
1NLO
,
3EN7
,
7NER
,
4DGG
,
7D5O
,
5OB2
,
7PVW
,
7A32
,
4OML
,
3G6G
,
1SRL
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41240 CSK
2
CSK [cytosol]
(R-HSA-203776)
CSK [plasma membrane]
(R-HSA-180499)
0.719
7
UniProt:P18433 PTPRA
1
PTPRA [plasma membrane]
(R-HSA-388755)
0.59
4
UniProt:Q00944
11
phospho-p-6Y-PTK2 [cytosol]
(R-GGA-354128)
phospho-p-Y397-PTK2 [cytosol]
(R-GGA-354068)
PTK2 [cytosol]
(R-GGA-201621)
PTK2(1-772) [cytosol]
(R-GGA-202827)
PTK2(773-1052) [cytosol]
(R-GGA-202829)
phospho-p-5Y-PTK2 [cytosol]
(R-GGA-5218711)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-GGA-5229006)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-GGA-5218694)
phospho-pY-PTK2 [cytosol]
(R-GGA-9632393)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-GGA-8874600)
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-GGA-8874613)
0.589
3
UniProt:Q9QWY8-1 ASAP1
0.581
3
UniProt:O88703
1
HCN2 [plasma membrane]
(R-MMU-977502)
0.581
5
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.564
2
UniProt:Q90738 AFAP1
0.564
3
UniProt:Q9Y4D1 DAAM1
1
DAAM1 [cytosol]
(R-HSA-351052)
0.556
3
UniProt:Q9QWY8-2 ASAP1
0.544
2
UniProt:P61980
2
Hnrnpk [nucleoplasm]
(R-RNO-4570532)
Hnrnpk [nucleoplasm]
(R-RNO-71945)
0.544
2
UniProt:P18052
1
PTPRA [plasma membrane]
(R-MMU-388755)
0.525
2
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