Reactome | phospho-MyrG-p-Y419-SRC [plasma membrane]

phospho-MyrG-p-Y419-SRC [plasma membrane]

Stable Identifier

R-GGA-1810408

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

P00523

Locations in the PathwayBrowser for interactor UniProt:P18052"

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External Reference Information

External Reference

UniProt:P00523 SRC

Gene Names

SRC

Chain

initiator methionine:1, chain:2-533

Reference Genes

BioGPS Gene:396442 SRC

ENSEMBL:ENSGALG00000003855 SRC

KEGG Gene (Gallus gallus):396442 SRC

Monarch:396442 SRC

NCBI Gene:396442 SRC

Reference Transcript

Other Identifiers

396442

GO:0000166

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005743

GO:0005768

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0006464

GO:0006468

GO:0006950

GO:0007049

GO:0007155

GO:0007165

GO:0007169

GO:0007173

GO:0008150

GO:0008219

GO:0008283

GO:0010008

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0019899

GO:0019903

GO:0020037

GO:0030054

GO:0030154

GO:0031234

GO:0031410

GO:0032991

GO:0036035

GO:0038083

GO:0042127

GO:0042592

GO:0043167

GO:0043226

GO:0045087

GO:0045453

GO:0048471

GO:0048856

GO:0050847

GO:0051726

GO:0070851

GO:0071253

GO:2001237

GO:2001243

GT_A_87_P009203

GT_A_87_P070256

GT_A_87_P130953

GT_A_87_P281733

GT_A_87_P300418

Gga.277.1.S1_at

Gga.4959.1.S1_s_at

Gga.9449.1.S1_at

GgaAffx.26027.1.S1_at

Participant Of

hasComponent

output

SRC phosphorylates RUNX3

input

hasMember

p-Y419/420/426-N-myristoyl-SRC/FYN/YES1 [plasma membrane]

This entity regulates

Negatively

RUNX3 translocates to the nucleus

Other forms of this molecule

SRC-2 [plasma membrane]

SRC [cytosol]

phospho-p-Y416-SRC [cytosol]

MyrG-SRC [plasma membrane]

Src [cytosol]

phospho-p-Y419-SRC [cytosol]

phospho-MyrG,p-Y530-SRC [plasma membrane]

SRC-2 [cytosol]

Inferred From

MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)

MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)

Modified Residues

Name

N-myristoylglycine at 2 (in Homo sapiens)

Coordinate

PsiMod Name

N-myristoylglycine [MOD:00068]

PsiMod Definition

A protein modification that effectively converts a glycine residue to N-myristoylglycine.

Name

O4'-phospho-L-tyrosine at 419 (in Homo sapiens)

Coordinate

419

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_990788.2, XP_015151834.1

ZINC - Investigational

SRC_CHICK

ZINC - World Drugs

SRC_CHICK

OpenTargets

ENSG00000197122

ZINC - FDA approved

SRC_CHICK

ZINC - Substances

SRC_CHICK

Ensembl

ENSGALP00000054990, ENSGALP00000068298, ENSGALT00000070498, ENSGALT00000093274, ENSGALP00000049896, ENSGALT00000061823, ENSGALG00000003855

ZINC target

P00523

PRO

P00523

ZINC - Predictions - Purchasable

SRC_CHICK

PDB

5EC7, 3EL8, 3F6X, 3SVV, 4AGW, 6XVN, 3EN4, 4DGG, 5TEH, 3G6G, 5T0P, 5OB0, 6XX5, 4OMO, 3F3V, 4HVV, 4OMM, 3UQG, 3U51, 4RTZ, 1F2F, 3G5D, 4RTV, 3LOK, 4LGG, 3FJ5, 1NLO, 3D7T, 3EL7, 4LE9, 5XP7, 1F1W, 3EN7, 4JZ4, 4LGH, 5OB2, 5OAV, 1SRM, 3U4W, 3F3U, 4MCV, 4OMN, 4YBK, 6XX2, 6HVF, 4HVU, 3TZ9, 5I11, 1SRL, 3UQF, 4RTY, 3GEQ, 1PRM, 5D12, 4U5J, 5D10, 4RTU, 3EN6, 5BMM, 6XVO, 2QI8, 3DQX, 6XVM, 5J5S, 3QLG, 4FIC, 4JZ3, 2HWP, 5K9I, 5SYS, 6XX4, 4YBJ, 3TZ8, 2PTK, 1RLQ, 3F3T, 3OF0, 4OML, 4RTX, 1PRL, 5D11, 4O2P, 2QLQ, 3EN5, 2QQ7, 3DQW, 5XP5, 3G6H, 2OIQ, 1P13, 3QLF, 5OB1, 6WIW, 4OMQ, 4QT7, 4OMP, 2HWO, 3OEZ, 6XX3, 3F3W, 3TZ7, 5SWH, 6HVE, 4HVW, 3D7U, 1RLP, 4RTW, 5ECA, 1NLP

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P41240 CSK	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.719	7
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.59	4
UniProt:Q00944	11	phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-GGA-8874613) phospho-pY-PTK2 [cytosol] (R-GGA-9632393) phospho-p-Y194,Y397-PTK2 [cytosol] (R-GGA-8874600) PTK2(773-1052) [cytosol] (R-GGA-202829) PTK2(1-772) [cytosol] (R-GGA-202827) phospho-p-5Y-PTK2 [cytosol] (R-GGA-5218711) phospho-p-5Y,S732-PTK2 [cytosol] (R-GGA-5229006) phospho-p-6Y,S732-PTK2 [cytosol] (R-GGA-5218694) PTK2 [cytosol] (R-GGA-201621) phospho-p-Y397-PTK2 [cytosol] (R-GGA-354068) phospho-p-6Y-PTK2 [cytosol] (R-GGA-354128)	0.589	3
UniProt:O88703	1	Hcn2 [plasma membrane] (R-MMU-977502)	0.581	5
UniProt:Q9QWY8-1 ASAP1			0.581	3
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.564	2
UniProt:Q90738 AFAP1			0.564	3
UniProt:Q9Y4D1 DAAM1	1	DAAM1 [cytosol] (R-HSA-351052)	0.556	3
UniProt:P61980	2	Hnrnpk [nucleoplasm] (R-RNO-71945) Hnrnpk [nucleoplasm] (R-RNO-4570532)	0.544	2
UniProt:Q9QWY8-2 ASAP1			0.544	2
UniProt:P18052	1	Ptpra [plasma membrane] (R-MMU-388755)	0.525	2

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