Reactome | phospho-p-Y371-CBL [cytosol]

phospho-p-Y371-CBL [cytosol]

Stable Identifier

R-GGA-182940

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

F1NXW5

Locations in the PathwayBrowser

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Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
    - BAR domain proteins recruit dynamin (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Gallus gallus)
      - CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
    - Cargo recognition for clathrin-mediated endocytosis (Gallus gallus)
      - Epsin family proteins bind ubiquitinated cargo (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
    - Clathrin recruits PIK3C2A (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
    - RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
    - SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        CLASP proteins:cargo [plasma membrane] (Gallus gallus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        ubiquitinated cargo [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Gallus gallus)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Gallus gallus)
        
        p-Y371-CBL:GRB2 [cytosol] (Gallus gallus)
        
        phospho-p-Y371-CBL [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:F1NXW5

Reference Genes

ENSEMBL:ENSGALG00000029077

Participates

as a component of

Other forms of this molecule

phospho-p-Y-CBL [cytosol]

phospho-p-Y371-CBL [plasma membrane]

phospho-PolyUb,p-Y700,Y731,Y774-CBL [cytosol]

phospho-p-Y700,Y731,Y774-CBL [cytosol]

CBL [cytosol]

Inferred From

p-Y371-CBL [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 371 (in Homo sapiens)

Coordinate

371

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

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