arginine + H2O => ornithine + urea

Stable Identifier
R-GGA-187632
Type
Reaction [transition]
Species
Gallus gallus
Compartment
mitochondrial matrix
ReviewStatus
5/5
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arginine + H2O => ornithine + urea
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Arginase (ARG1) catalyzes the hydrolysis of arginine to form ornithine and urea. In chickens, the enzyme is localized in the mitochondrial matrix, is expressed at high levels in kidney, and only at low levels in liver (Kadowaki and Nesheim 1979; Tamir and Ratner 1963). Its physiological function may be to generate ornithine as a first step in the synthesis of polyamines (Grillo et al. 1983); the fate of the urea that is also generated is unknown. The ARG1 gene has not been directly studied but rather has been identified computationally in the ENSEMBL chicken gene set as a single open reading frame capable of encoding a protein similar to human ARG1.
Literature References
PubMed ID Title Journal Year
6617953 Arginase, ornithine decarboxylase and S-adenosylmethionine decarboxylase in chicken brain and retina

Fossa, T, Dianzani, U, Grillo, MA

Int J Biochem 1983
14064979 Enzymes of arginine metabolism in chicks

Ratner, S, Tamir, H

Arch Biochem Biophys 1963
318375 An assay for arginase in chicken kidney

Kadowaki, H, Nesheim, MC

Comp Biochem Physiol B 1978
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Output
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Catalyst Activity

arginase activity of ARG2 [mitochondrial matrix]

Physical Entity
ARG2 [mitochondrial matrix] (Gallus gallus)
Activity
arginase activity (GO:0004053)
Authored
Schmidt, C  (2006-09-20)
Reviewed
D'Eustachio, P  (2008-09-10)
Created
Schmidt, C  (2006-09-20)
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