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phospho-AKT1 [cytosol]
Stable Identifier
R-GGA-198356
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
p-T308,S473-AKT1, A0A3Q2U4X3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
Mitotic G1 phase and G1/S transition (Gallus gallus)
G1/S Transition (Gallus gallus)
Cyclin E associated events during G1/S transition (Gallus gallus)
AKT phosphorylates p21Cip1 and p27Kip1 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
S Phase (Gallus gallus)
Cyclin A:Cdk2-associated events at S phase entry (Gallus gallus)
AKT phosphorylates p21Cip1 and p27Kip1 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
KEAP1-NFE2L2 pathway (Gallus gallus)
NFE2L2 translocates from cytosol to nucleoplasm (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by TP53 (Gallus gallus)
Regulation of TP53 Activity (Gallus gallus)
Regulation of TP53 Expression and Degradation (Gallus gallus)
Regulation of TP53 Degradation (Gallus gallus)
AKT phosphorylates MDM2 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
TP53 Regulates Metabolic Genes (Gallus gallus)
AKT phosphorylates TSC2, inhibiting it (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Costimulation by the CD28 family (Gallus gallus)
CD28 co-stimulation (Gallus gallus)
CD28 dependent PI3K/Akt signaling (Gallus gallus)
AKT interacts and phosphorylates Cot (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Metabolism (Gallus gallus)
Metabolism of nitric oxide: NOS3 activation and regulation (Gallus gallus)
eNOS activation (Gallus gallus)
AKT1 binds eNOS complex via HSP90 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT1 phosphorylates eNOS (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Uncoupled eNOS favours the formation of superoxide (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of cofactors (Gallus gallus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Gallus gallus)
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Metabolism of RNA (Gallus gallus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Gallus gallus)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Gallus gallus)
Protein Kinase B/Akt phosphorylates BRF1 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
AKT phosphorylates targets in the cytosol (Gallus gallus)
AKT phosphorylates IKKalpha (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT phosphorylates MDM2 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT phosphorylates MKRN1 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT phosphorylates TSC2, inhibiting it (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT phosphorylates caspase-9 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT phosphorylates p21Cip1 and p27Kip1 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PHLPP dephosphorylates S473 in AKT (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
PTEN Regulation (Gallus gallus)
Regulation of PTEN stability and activity (Gallus gallus)
AKT phosphorylates MKRN1 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Signaling by NOTCH (Gallus gallus)
Signaling by NOTCH4 (Gallus gallus)
Negative regulation of NOTCH4 signaling (Gallus gallus)
AKT1 phosphorylates NOTCH4 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ERBB2 (Gallus gallus)
Downregulation of ERBB2 signaling (Gallus gallus)
Downregulation of ERBB2:ERBB3 signaling (Gallus gallus)
Phosphorylation of USP8 by P-AKT (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
VEGFR2 mediated vascular permeability (Gallus gallus)
AKT1 binds eNOS complex via HSP90 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT1 phosphorylates eNOS (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Vesicle-mediated transport (Gallus gallus)
Membrane Trafficking (Gallus gallus)
Rab regulation of trafficking (Gallus gallus)
RAB GEFs exchange GTP for GDP on RABs (Gallus gallus)
Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A3Q2U4X3
Gene Names
AKT1
Reference Genes
ENSEMBL:ENSGALG00000011620
ENSEMBL:ENSGALG00010017364.1 AKT1
Other Identifiers
395928
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005975
GO:0005978
GO:0006006
GO:0006091
GO:0006468
GO:0008643
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0035556
GO:0036211
GO:0140096
GT_A_87_P057766
GT_Sp_Chicken_CO763759_8420
Gga.3875.1.S1_at
Gga.3875.2.S1_a_at
Participates
as a component of
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
as an input of
AKT1 binds eNOS complex via HSP90 (Gallus gallus)
PHLPP dephosphorylates S473 in AKT (Gallus gallus)
This entity regulates
Positively
NFE2L2 translocates from cytosol to nucleoplasm
(Gallus gallus)
Other forms of this molecule
phospho-AKT1 [plasma membrane]
phospho-AKT1 [cytosol]
AKT1 [cytosol]
AKT1 [plasma membrane]
phospho-AKT1 [plasma membrane]
phospho-AKT1 [nucleoplasm]
Inferred From
p-T,p-S-AKT [cytosol]
(Homo sapiens)
p-T308,S473-AKT1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 308 (in Homo sapiens)
Coordinate
308
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 473 (in Homo sapiens)
Coordinate
473
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
OpenTargets
ENSG00000142208
Ensembl
ENSGALG00010017364
,
ENSGALP00010024517
,
ENSGALT00010041909
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