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phospho-AKT1 [cytosol]
Stable Identifier
R-GGA-198356
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
p-T308,S473-AKT1, A0A3Q2U4X3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
Mitotic G1 phase and G1/S transition (Gallus gallus)
G1/S Transition (Gallus gallus)
Cyclin E associated events during G1/S transition (Gallus gallus)
AKT phosphorylates p21Cip1 and p27Kip1 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
S Phase (Gallus gallus)
Cyclin A:Cdk2-associated events at S phase entry (Gallus gallus)
AKT phosphorylates p21Cip1 and p27Kip1 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to chemical stress (Gallus gallus)
KEAP1-NFE2L2 pathway (Gallus gallus)
NFE2L2 translocates from cytosol to nucleoplasm (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Gene expression (Transcription) (Gallus gallus)
RNA Polymerase II Transcription (Gallus gallus)
Generic Transcription Pathway (Gallus gallus)
Transcriptional Regulation by TP53 (Gallus gallus)
Regulation of TP53 Activity (Gallus gallus)
Regulation of TP53 Expression and Degradation (Gallus gallus)
Regulation of TP53 Degradation (Gallus gallus)
AKT phosphorylates MDM2 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
TP53 Regulates Metabolic Genes (Gallus gallus)
AKT phosphorylates TSC2, inhibiting it (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Regulation of T cell activation by CD28 family (Gallus gallus)
Co-stimulation by CD28 (Gallus gallus)
CD28 dependent PI3K/Akt signaling (Gallus gallus)
AKT interacts and phosphorylates Cot (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Metabolism (Gallus gallus)
Metabolism of nitric oxide: NOS3 activation and regulation (Gallus gallus)
eNOS activation (Gallus gallus)
AKT1 binds eNOS complex via HSP90 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT1 phosphorylates eNOS (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Uncoupled eNOS favours the formation of superoxide (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of cofactors (Gallus gallus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Gallus gallus)
BH2 binding can lead to eNOS uncoupling (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Metabolism of RNA (Gallus gallus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Gallus gallus)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Gallus gallus)
Protein Kinase B/Akt phosphorylates BRF1 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
AKT phosphorylates targets in the cytosol (Gallus gallus)
AKT phosphorylates IKKalpha (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT phosphorylates MDM2 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT phosphorylates MKRN1 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT phosphorylates TSC2, inhibiting it (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT phosphorylates caspase-9 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT phosphorylates p21Cip1 and p27Kip1 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PHLPP dephosphorylates S473 in AKT (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
PTEN Regulation (Gallus gallus)
Regulation of PTEN stability and activity (Gallus gallus)
AKT phosphorylates MKRN1 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Signaling by NOTCH (Gallus gallus)
Signaling by NOTCH4 (Gallus gallus)
Negative regulation of NOTCH4 signaling (Gallus gallus)
AKT1 phosphorylates NOTCH4 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ERBB2 (Gallus gallus)
Downregulation of ERBB2 signaling (Gallus gallus)
Downregulation of ERBB2:ERBB3 signaling (Gallus gallus)
Phosphorylation of USP8 by P-AKT (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
VEGFR2 mediated vascular permeability (Gallus gallus)
AKT1 binds eNOS complex via HSP90 (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
AKT1 phosphorylates eNOS (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
eNOS synthesizes NO (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
Vesicle-mediated transport (Gallus gallus)
Membrane Trafficking (Gallus gallus)
Rab regulation of trafficking (Gallus gallus)
RAB GEFs exchange GTP for GDP on RABs (Gallus gallus)
Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Gallus gallus)
phospho-AKT1 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A3Q2U4X3
Gene Names
AKT1
Reference Genes
BioGPS Gene:395928 AKT1
ENSEMBL:ENSGALG00000011620
Monarch:395928 AKT1
NCBI Gene:395928 AKT1
UCSC:A0A3Q2U4X3 AKT1
Reference Transcript
RefSeq:XM_046917865.1 AKT1
RefSeq:NM_205055.2 AKT1
RefSeq:NM_001396388.1 AKT1
RefSeq:XM_046941459.1 AKT1
RefSeq:NM_001396387.1 AKT1
Other Identifiers
395928
GO:0001649
GO:0001938
GO:0002042
GO:0003376
GO:0003824
GO:0004672
GO:0004674
GO:0004676
GO:0004677
GO:0004679
GO:0004694
GO:0004711
GO:0004712
GO:0005516
GO:0005524
GO:0005547
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005758
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005929
GO:0005975
GO:0005977
GO:0005978
GO:0005979
GO:0006006
GO:0006091
GO:0006325
GO:0006338
GO:0006355
GO:0006468
GO:0006606
GO:0006886
GO:0006913
GO:0006924
GO:0006954
GO:0007005
GO:0007173
GO:0007281
GO:0008286
GO:0008289
GO:0008637
GO:0009408
GO:0009725
GO:0010467
GO:0010507
GO:0010595
GO:0010628
GO:0010629
GO:0010748
GO:0010763
GO:0010765
GO:0010907
GO:0010975
GO:0012501
GO:0015630
GO:0016020
GO:0016301
GO:0016567
GO:0016740
GO:0019901
GO:0022414
GO:0022605
GO:0030154
GO:0030163
GO:0030235
GO:0030307
GO:0030334
GO:0030335
GO:0031397
GO:0031641
GO:0031663
GO:0031982
GO:0031999
GO:0032094
GO:0032287
GO:0032436
GO:0032869
GO:0032880
GO:0032991
GO:0034405
GO:0035175
GO:0035402
GO:0035403
GO:0035556
GO:0035655
GO:0035924
GO:0035979
GO:0036064
GO:0036294
GO:0042593
GO:0042802
GO:0042803
GO:0042981
GO:0043066
GO:0043161
GO:0043226
GO:0043325
GO:0043491
GO:0043536
GO:0044022
GO:0044023
GO:0044024
GO:0044025
GO:0045429
GO:0045600
GO:0045725
GO:0045861
GO:0045944
GO:0046326
GO:0046622
GO:0046889
GO:0048009
GO:0048266
GO:0048661
GO:0048856
GO:0048870
GO:0051146
GO:0061024
GO:0070141
GO:0070848
GO:0071356
GO:0071363
GO:0071364
GO:0071380
GO:0071889
GO:0072354
GO:0072371
GO:0072518
GO:0072655
GO:0072656
GO:0090201
GO:0097011
GO:0097194
GO:0098772
GO:0098978
GO:0099104
GO:0099175
GO:0106310
GO:0110002
GO:0140052
GO:0140096
GO:0140823
GO:0140855
GO:0140857
GO:0150033
GO:0160049
GO:1900087
GO:1900182
GO:1901653
GO:1902018
GO:1903038
GO:1903078
GO:1903898
GO:1904263
GO:1904515
GO:1905552
GO:1990090
GO:1990244
GO:2000010
GO:2000402
GO:2001243
GT_A_87_P057766
GT_Sp_Chicken_CO763759_8420
Gga.3875.1.S1_at
Gga.3875.2.S1_a_at
Participates
as a component of
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Gallus gallus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Gallus gallus)
as an input of
AKT1 binds eNOS complex via HSP90 (Gallus gallus)
PHLPP dephosphorylates S473 in AKT (Gallus gallus)
This entity regulates
Positively
NFE2L2 translocates from cytosol to nucleoplasm
(Gallus gallus)
Other forms of this molecule
phospho-AKT1 [cytosol]
phospho-AKT1 [plasma membrane]
phospho-AKT1 [cytosol]
AKT1 [cytosol]
AKT1 [plasma membrane]
phospho-AKT1 [plasma membrane]
phospho-AKT1 [nucleoplasm]
Inferred From
p-T,p-S-AKT [cytosol]
(Homo sapiens)
p-T308,S473-AKT1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 308 (in Homo sapiens)
Coordinate
308
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 473 (in Homo sapiens)
Coordinate
473
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_990386.2
,
XP_046797415.1
,
NP_001383316.1
,
NP_001383317.1
,
XP_046773821.1
ENSEMBL
ENSGALT00010041909
,
ENSGALP00010024517
,
ENSGALG00010017364
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