Reactome | ACTR3 [cytosol]

ACTR3 [cytosol]

Stable Identifier

R-GGA-200811

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

ACTR3, Q90WD0

Locations in the PathwayBrowser

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Developmental Biology (Gallus gallus)

- Nervous system development (Gallus gallus)
  - Axon guidance (Gallus gallus)
    - EPH-Ephrin signaling (Gallus gallus)
      - EPHB-mediated forward signaling (Gallus gallus)
        
        N-WASP binds ARP2/3 and G-actin (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)

Immune System (Gallus gallus)

- Innate Immune System (Gallus gallus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
    - Regulation of actin dynamics for phagocytic cup formation (Gallus gallus)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Gallus gallus)
        
        Mother filament:branching complex [cytosol] (Gallus gallus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
      - Branching and elongation of mother and daughter filaments (Gallus gallus)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
        
        Mother filament:branching complex:daughter filament [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
      - Detachment of WASP/WAVE (Gallus gallus)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
        
        Mother filament:branching complex [cytosol] (Gallus gallus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
      - Role of myosins in phagosome formation (Gallus gallus)
        
        Mother filament:branching complex:daughter filament [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
        
        Myosin-Actin filaments [cytosol] (Gallus gallus)
        
        Mother filament:branching complex:daughter filament [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
  - Signaling by Rho GTPases (Gallus gallus)
    - RHO GTPase Effectors (Gallus gallus)
      - RHO GTPases Activate WASPs and WAVEs (Gallus gallus)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Gallus gallus)
        
        Mother filament:branching complex [cytosol] (Gallus gallus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
        
        Branching and elongation of mother and daughter filaments (Gallus gallus)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
        
        Mother filament:branching complex:daughter filament [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
        
        Detachment of WASP/WAVE (Gallus gallus)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
        
        Mother filament:branching complex [cytosol] (Gallus gallus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Gallus gallus)
        
        ARP2/3 complex (ATP bound) [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)

Vesicle-mediated transport (Gallus gallus)

- Membrane Trafficking (Gallus gallus)
  - Clathrin-mediated endocytosis (Gallus gallus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
    - BAR domain proteins recruit dynamin (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
    - RAB5 and GAPVD1 bind AP-2 (Gallus gallus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
    - SNX9 recruits components of the actin polymerizing machinery (Gallus gallus)
      - ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Gallus gallus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Gallus gallus)
        
        ARP2/3 complex [cytosol] (Gallus gallus)
        
        ACTR3:ATP [cytosol] (Gallus gallus)
        
        ACTR3 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q90WD0

Gene Names

ACTR3

Reference Genes

BioGPS Gene:374197 ACTR3

ENSEMBL:ENSGALG00000012159

ENSEMBL:ENSGALG00010019319.1 ACTR3

ENSEMBL:ENSGALG00015022491 ACTR3

KEGG Gene (Gallus gallus):374197 ACTR3

Monarch:374197 ACTR3

NCBI Gene:374197 ACTR3

Reference Transcript

RefSeq:NM_204307.1 ACTR3

Other Identifiers

374197

GO:0000166

GO:0003779

GO:0005524

GO:0005634

GO:0005694

GO:0005737

GO:0005856

GO:0005885

GO:0006351

GO:0006355

GO:0007010

GO:0008092

GO:0034314

GO:0035861

GO:0042995

GO:0043226

GO:0045944

GO:0051015

Gga.4076.1.S1_at

Gga.8984.1.S1_at

Participates

as a component of

ACTR3:ATP [cytosol] (Gallus gallus)

Inferred From

ACTR3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_989638.1

OpenTargets

ENSG00000115091

Ensembl

ENSGALP00010027884, ENSGALT00010046870, ENSGALG00010019319

PRO

Q90WD0

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