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PTK2 [cytosol]
Stable Identifier
R-GGA-201621
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
Q00944
Locations in the PathwayBrowser for interactor UniProt:P08581
Expand all
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Translocation of PTK2 to Focal complexes (Gallus gallus)
PTK2 [cytosol] (Gallus gallus)
Programmed Cell Death (Gallus gallus)
Apoptosis (Gallus gallus)
Apoptotic execution phase (Gallus gallus)
Apoptotic cleavage of cellular proteins (Gallus gallus)
Caspase-mediated cleavage of FADK 1 (Gallus gallus)
PTK2 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Translocation of PTK2 to Focal complexes (Gallus gallus)
PTK2 [cytosol] (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
PTK2 binds activated EGFR (Gallus gallus)
PTK2 [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by MET (Gallus gallus)
MET promotes cell motility (Gallus gallus)
MET activates PTK2 signaling (Gallus gallus)
PTK2 binds activated MET (Gallus gallus)
PTK2 [cytosol] (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Gallus gallus)
PTK2 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q00944
Reference Genes
ENSEMBL:ENSGALG00000031741
KEGG Gene (Gallus gallus):396416
Reference Transcript
RefSeq:NM_205435.1
Participates
as an input of
Translocation of PTK2 to Focal complexes (Gallus gallus)
PTK2 binds activated EGFR (Gallus gallus)
PTK2 binds activated MET (Gallus gallus)
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Gallus gallus)
Caspase-mediated cleavage of FADK 1 (Gallus gallus)
as a component of
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Gallus gallus)
as a member of
Src-kinases [cytosol] (Gallus gallus)
Other forms of this molecule
phospho-pY-PTK2 [cytosol]
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
phospho-p-Y194,Y397-PTK2 [cytosol]
phospho-p-5Y-PTK2 [cytosol]
phospho-p-5Y,S732-PTK2 [cytosol]
phospho-p-6Y,S732-PTK2 [cytosol]
PTK2(773-1052) [cytosol]
PTK2(1-772) [cytosol]
phospho-p-Y397-PTK2 [cytosol]
phospho-p-6Y-PTK2 [cytosol]
Inferred From
PTK2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_990766.1
IntEnz
2.7.10.2
PRO
Q00944
PDB
1PV3
,
2J0L
,
2J0M
,
4D5H
,
1KTM
,
6TY4
,
6TY3
,
4D4R
,
2JKK
,
4D5K
,
6CB0
,
2JKM
,
4D4S
,
2L6F
,
4BRX
,
2JKO
,
6GCR
,
3ZDT
,
2L6H
,
2L6G
,
2AEH
,
4C7T
,
2JKQ
,
4D4V
,
4D55
,
1QVX
,
6GCX
,
6GCW
,
4D4Y
,
2J0J
,
2AL6
,
4CYE
,
2J0K
,
4D58
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00944
11
phospho-pY-PTK2 [cytosol]
(R-GGA-9632393)
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-GGA-8874613)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-GGA-8874600)
phospho-p-5Y-PTK2 [cytosol]
(R-GGA-5218711)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-GGA-5229006)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-GGA-5218694)
PTK2(773-1052) [cytosol]
(R-GGA-202829)
PTK2(1-772) [cytosol]
(R-GGA-202827)
PTK2 [cytosol]
(R-GGA-201621)
phospho-p-Y397-PTK2 [cytosol]
(R-GGA-354068)
phospho-p-6Y-PTK2 [cytosol]
(R-GGA-354128)
0.656
3
UniProt:P61157 ACTR3
1
ARP3 [cytosol]
(R-BTA-419940)
0.612
5
UniProt:P49024 PAXI
0.609
2
UniProt:P08581 MET
7
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
MET [plasma membrane]
(R-HSA-419603)
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
0.602
5
UniProt:P00523 SRC
9
SRC [cytosol]
(R-GGA-9628701)
phospho-p-Y419-SRC [cytosol]
(R-GGA-8964276)
MyrG-SRC [plasma membrane]
(R-GGA-8876922)
Src [cytosol]
(R-GGA-3928468)
SRC-1 [plasma membrane]
(R-GGA-65043)
phospho-p-Y419-SRC [cytosol]
(R-GGA-377592)
phospho-MyrG,p-Y530-SRC [plasma membrane]
(R-GGA-377598)
phospho-MyrG-p-Y419-SRC [plasma membrane]
(R-GGA-1810408)
SRC-2 [cytosol]
(R-GGA-191648)
0.589
3
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