Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-p-Y113,128,145-LCP2 [cytosol]
Stable Identifier
R-GGA-202175
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
A0A3S5ZPP7
Locations in the PathwayBrowser
Expand all
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
GPVI-mediated activation cascade (Gallus gallus)
SLP-76 stimulates PLC gamma 2 (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Syk activation leads to SLP-76 activation (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-SLP-76 binds VAV (Gallus gallus)
p-SLP-76:VAV [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
TCR signaling (Gallus gallus)
Generation of second messenger molecules (Gallus gallus)
Phosphorylation of PLC-gamma1 (Gallus gallus)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Gallus gallus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Gallus gallus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-SLP-76 binds ADAP (Gallus gallus)
p-SLP-76:ADAP [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
DAP12 interactions (Gallus gallus)
DAP12 signaling (Gallus gallus)
Activation of RAC1 by VAV2/3 (Gallus gallus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Phosphorylation and activation of VAV2/VAV3 by SYK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Phosphorylation of BTK by p-SYK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-SYK/p-BTK [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Phosphorylation of SLP-76 by p-SYK (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Recruitment of VAV and BTK to p-SLP-76 (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Release of p-PLCG1 (Gallus gallus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated Ca+2 mobilization (Gallus gallus)
Autophosphorylation of BTK/ITK (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Hydrolysis of PIP2 by PLCG (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
FCERI mediated MAPK activation (Gallus gallus)
Activation of RAC1 by VAV (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Autophosphorylation of PAK (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Phosphorylation and activation of VAV (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Recruitment of PAK to the membrane by binding active RAC1 (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Gallus gallus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
Recruitment of VAV to p-SLP-76 (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Gallus gallus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A3S5ZPP7
Reference Genes
ENSEMBL:ENSGALG00000002113
Participates
as an input of
p-SLP-76 binds VAV (Gallus gallus)
p-SLP-76 binds ADAP (Gallus gallus)
as a component of
p-SLP-76:VAV [cytosol] (Gallus gallus)
p-SLP-76:ADAP [cytosol] (Gallus gallus)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Gallus gallus)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Gallus gallus)
as an output of
Syk activation leads to SLP-76 activation (Gallus gallus)
This entity regulates
Positively
SLP-76 stimulates PLC gamma 2
(Gallus gallus)
Other forms of this molecule
LCP2 [cytosol]
Inferred From
p-Y113,128,145-LCP2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 113 (in Homo sapiens)
Coordinate
113
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 128 (in Homo sapiens)
Coordinate
128
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 145 (in Homo sapiens)
Coordinate
145
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text