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phospho-p-Y394-LCK [cytosol]
Stable Identifier
R-GGA-202308
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
F1NP54
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Regulation of T cell activation by CD28 family (Gallus gallus)
Co-inhibition by PD-1 (Gallus gallus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Gallus gallus)
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
TCR signaling (Gallus gallus)
Generation of second messenger molecules (Gallus gallus)
Phosphorylation of PLC-gamma1 (Gallus gallus)
Activated ZAP-70 [plasma membrane] (Gallus gallus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
Phosphorylation of CD3 and TCR zeta chains (Gallus gallus)
Activation of Lck (Gallus gallus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
Inactivation of LCK by PTPN22 (Gallus gallus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
Phosphorylation of ITAM motifs in CD3 complexes (Gallus gallus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
Translocation of ZAP-70 to Immunological synapse (Gallus gallus)
Activation of ZAP-70 (Gallus gallus)
Activated ZAP-70 [plasma membrane] (Gallus gallus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
phospho tyrosine ZAP-70 [plasma membrane] (Gallus gallus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
PTPN22 dephosphorylates ZAP70 (Gallus gallus)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Gallus gallus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
phospho tyrosine ZAP-70 [plasma membrane] (Gallus gallus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
Phosphorylation of ZAP-70 by Lck (Gallus gallus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Gallus gallus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
phospho tyrosine ZAP-70 [plasma membrane] (Gallus gallus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
Recruitment of ZAP-70 to phosphorylated ITAMs (Gallus gallus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Gallus gallus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
phospho-p-Y394-LCK [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:F1NP54
Reference Genes
ENSEMBL:ENSGALG00000000466
UCSC:F1NP54
Participates
as a component of
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Gallus gallus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Gallus gallus)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
Other forms of this molecule
phospho-p-Y505-LCK [plasma membrane]
LCK [cytosol]
Inferred From
p-Y394-LCK [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 394 (in Homo sapiens)
Coordinate
394
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
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