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phospho-p-JAK2 [cytosol]
Stable Identifier
R-GGA-210621
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
A0A3Q3B2A8
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by CSF3 (G-CSF) (Gallus gallus)
Inactivation of CSF3 (G-CSF) signaling (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Gallus gallus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Gallus gallus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-12 family signaling (Gallus gallus)
Interleukin-12 signaling (Gallus gallus)
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Gallus gallus)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
Interleukin-23 signaling (Gallus gallus)
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
Interleukin-35 Signalling (Gallus gallus)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Gallus gallus)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Gallus gallus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Gallus gallus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Gallus gallus)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Gallus gallus)
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Gallus gallus)
IL6ST:p-JAK1:p-JAK2:p-TYK2 [plasma membrane] (Gallus gallus)
p-JAK1,p-JAK2,p-TYK2 [cytosol] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Gallus gallus)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
STAT1 associates with IL6ST:IL6ST (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
STAT4 binds IL12RB2:IL12RB2 (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
p-STAT1 dissociates from IL6ST:IL6ST (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-p-JAK2 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A3Q3B2A8
Reference Genes
ENSEMBL:ENSGALG00000015027
Participates
as a component of
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Gallus gallus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Gallus gallus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Gallus gallus)
as a member of
p-JAK1,p-JAK2,p-TYK2 [cytosol] (Gallus gallus)
Other forms of this molecule
phospho-p-Y1007,Y1008-JAK2 [cytosol]
phospho-p-Y813-JAK2 [cytosol]
JAK2 [endosome lumen]
phospho-p-12Y-JAK2 [cytosol]
phospho-p-Y1007-JAK2 [cytosol]
JAK2 [cytosol]
Inferred From
p-JAK2 [cytosol]
(Homo sapiens)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
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