Cleavage of surface-bound factor B

Stable Identifier
R-GGA-2132074
Type
Reaction [transition]
Species
Gallus gallus
Compartment
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Human factor B is cleaved by factor D yielding a small fragment Ba and a surface-bound C3 convertase (C3b:Bb). Although an orthologue of human factor D is not identified in the chicken genome, published data demonstrates the presence of alternative complement pathway (ACP) activity in chicken [Otha H et al. 1983; Otha H et al. 1984; Laursen I & Koch C 1989; Mavrodis M et al. 1995; Koch C 1986]. This Reactome project annotates a hypothetical chicken factor D and describes cleavage of a factor B-like protease into an N-terminal Ba fragment of 37 kDa and a C-terminal Bb fragment of 60 kDa. These two fragments of chicken factor B-like protease were purified and characterized [Kjalke M et al. 1993].

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Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of complement factor D [extracellular region]
Physical Entity
Activity
Inferred From
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