Vitronectin binds to C5b-C7 complex

Stable Identifier
R-GGA-2132136
Type
Reaction [binding]
Species
Gallus gallus
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Vitronectin binds to C5b-C7 complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Human vitronectin interacts with C5b:C6:C7 complex preventing it from binding the cell membrane.

Vitronectin transcripts were detected in the brain, liver and spleen of adult chickens. The polypeptide sequence of chicken vitronectin exhibits 57% identity with its human orthologue. Chicken events involving vitronectin have not been verified experimentally but are inferred from properties of the orthologous human proteins.

Literature References
PubMed ID Title Journal Year
2466593 Complement S-protein (vitronectin) is associated with cytolytic membrane-bound C5b-9 complexes

Halstensen, TS, Hugo, F, Preissner, KT, Käflein, R, Mollnes, TE, Bhakdi, S

Clin. Exp. Immunol. 1988
20067805 Cloning of the sixth complement component and, spatial and temporal expression profile of MAC structural and regulatory genes in chicken

Mikrou, A, Zarkadis, IK

Dev Comp Immunol 2010
Participants
Input
Output
Participates
as an event of
Inferred From
Vitronectin (VTN) binds to C5b:C6:C7 (Homo sapiens)
Authored
Shamovsky, V  (2012-12-20)
Reviewed
D'Eustachio, P  (2012-11-07)
Jupe, S  (2013-01-31)
Created
Shamovsky, V  (2012-02-21)
Cite Us!