MBL or ficolin binds an oligosaccharide pattern on the target cell surface

Stable Identifier
R-GGA-2132187
Type
Reaction [transition]
Species
Gallus gallus
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Both mannose-binding lectin (MBL) and ficolins are lectins, that circulate in plasma as oligomers of structural subunits. Each subunit is composed of three identical peptides and contains an amino-terminal cysteine-rich region, a collagen-like domain, a neck region and a carboxy-terminal carbohydrate-binding domain. However, the carbohydrate-binding domains of MBL and ficolins are quite different. A carbohydrate-recognition domain (CRD) is in MBL and a fibrinogen-like domain is in ficolins [Holmskov U et al 2003; Endo Y et al 2006; Thiel S and Gadjeva M 2009]. MBL recognizes certain carbohydrates such as mannose and GlcNAc. Mammalian ficolins like MBL possess carbohydrate-binding activity. Different ficolins have distinct recognition specificities [Matsushita M et al 1996; Lu J and Le Y 1998; Gout E et al 2009].

Mammals usually possess two MBL genes and two or three ficolin genes, but only one of each has been found in the chicken genome. Several studies investigated the function of chicken MBL upon avian viral infections with infectious laryngotracheitis virus (ILTV), infectious bursal disease virus (IBDV) and infectious bronchitis virus (IBV) [Nielsen OL et al 1998, 1999; Laursen SB and Nielsen OL 2000; Juul-Madsen HR et al 2003, 2007]. Similar to mammals, chickens produce MBL in the hepatocytes, secrete it into the blood, and upregulate the production during acute stages of virus infections. The serum concentration of chicken MBL increased two- to three-fold in virus-infected chickens compared with noninfected controls, indicating that chicken MBL is a minor acute phase mediator. Chicken MBL was also reported to mediate host response against bacterial infection such as Pasteurella multocida [Schou TW et al 2010]. The ability of chicken MBL to activate the complement cascade was tested in a heterologous system by deposition of human C4 on the chicken MBL:MASP complex in response to infection with avian IBV. The complement activation was directly associated with the concentration of MBL in serum [Laursen SB and Nielsen OL 2000; Juul-Madsen HR et al 2003, Norup LR and Juul-Madsen HR 2007].

Literature References
PubMed ID Title Journal Year
18158730 Mannan-binding lectin (MBL) serum concentration in relation to propagation of infectious bronchitis virus (IBV) in chickens

Juul-Madsen, HR, Norup, LR, Handberg, KJ, Jørgensen, PH

Viral Immunol 2007
12524383 Collections and ficolins: humoral lectins of the innate immune defense

Holmskov, U, Thiel, S, Jensenius, JC

Annu Rev Immunol 2003
15199963 The lectin-complement pathway--its role in innate immunity and evolution

Fujita, T, Matsushita, M, Endo, Y

Immunol Rev 2004
12223281 Collectins and ficolins: sugar pattern recognition molecules of the mammalian innate immune system

Lu, J, Teh, C, Kishore, U, Reid, KB

Biochim Biophys Acta 2002
18922580 Mannan-binding lectin (MBL) in two chicken breeds and the correlation with experimental Pasteurella multocida infection

Schou, TW, Permin, A, Christensen, JP, Cu, HP, Juul-Madsen, HR

Comp Immunol Microbiol Infect Dis 2010
8576206 A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin

Matsushita, M, Endo, Y, Taira, S, Sato, Y, Fujita, T, Ichikawa, N, Nakata, M, Mizuochi, T

J Biol Chem 1996
20032467 Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin

Gout, E, Garlatti, V, Smith, DF, Lacroix, M, Dumestre-Pérard, C, Lunardi, T, Martin, L, Cesbron, JY, Arlaud, GJ, Gaboriaud, C, Thielens, NM

J Biol Chem 2010
10717281 Mannan-binding lectin (MBL) in chickens: molecular and functional aspects

Laursen, SB, Nielsen, OL

Dev Comp Immunol 2000
9708196 Immunohistochemical investigation of the tissue distribution of mannan-binding lectin in non-infected and virus-infected chickens

Nielsen, OL, Jørgensen, PH, Hedemand, J, Jensenius, JC, Koch, C, Laursen, SB

Immunology 1998
10507370 Serum levels of chicken mannan-binding lectin (MBL) during virus infections; indication that chicken MBL is an acute phase reactant

Nielsen, OL, Jensenius, JC, Jørgensen, PH, Laursen, SB

Vet Immunol Immunopathol 1999
  Target Pattern Recognition in Innate Immunity

Kishore, U

  2009
  Current Topics in Complement

Lambris, JD

  2008
12619800 Serum levels of mannan-binding lectin in chickens prior to and during experimental infection with avian infectious bronchitis virus

Juul-Madsen, HR, Munch, M, Handberg, KJ, Sørensen, P, Johnson, AA, Norup, LR, Jørgensen, PH

Poult Sci 2003
17954581 An assay for measuring the mannan-binding lectin pathway of complement activation in chickens

Norup, LR, Juul-Madsen, HR

Poult Sci 2007
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