C3b fragment binds to the target cell surface

Stable Identifier
R-GGA-2132210
Type
Reaction [binding]
Species
Gallus gallus
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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C3b fragment binds to the target cell surface
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C3b molecules are continuously deposited onto target surfaces. Deposition occurs through a covalent linkage between a thioester that is exposed upon C3 cleavage, and a hydroxyl or other nucleophilic group of glycoproteins on the target cell surface [Smiley ML & Friedman HA 1985; Lewis LA et al. 2008].
Literature References
PubMed ID Title Journal Year
2991604 Binding of complement component C3b to glycoprotein C is modulated by sialic acid on herpes simplex virus type 1-infected cells

Friedman, HM, Smiley, ML

J. Virol. 1985
7532662 Isolation, primary structure, and evolution of the third component of chicken complement and evidence for a new member of the alpha 2-macroglobulin family

Mavroidis, M, Lambris, JD, Sunyer, JO

J Immunol 1995
17984207 Defining targets for complement components C4b and C3b on the pathogenic neisseriae

Getzlaff, S, Vogel, U, Blom, AM, Lewis, LA, Rice, PA, Prasad, A, Gulati, S, Ram, S

Infect. Immun. 2008
Participants
Input
Output
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as an event of
Inferred From
C3b binds to cell surface (Homo sapiens)
Authored
Shamovsky, V  (2012-12-20)
Reviewed
D'Eustachio, P  (2012-11-07)
Jupe, S  (2013-01-31)
Created
Shamovsky, V  (2012-02-21)
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