C3b fragment binds to the target cell surface

Stable Identifier
R-GGA-2132210
Type
Reaction [binding]
Species
Gallus gallus
Compartment
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C3b molecules are continuously deposited onto target surfaces. Deposition occurs through a covalent linkage between a thioester that is exposed upon C3 cleavage, and a hydroxyl or other nucleophilic group of glycoproteins on the target cell surface [Smiley ML & Friedman HA 1985; Lewis LA et al. 2008].

Literature References
PubMed ID Title Journal Year
7532662 Isolation, primary structure, and evolution of the third component of chicken complement and evidence for a new member of the alpha 2-macroglobulin family

Mavroidis, M, Sunyer, JO, Lambris, JD

J Immunol 1995
2991604 Binding of complement component C3b to glycoprotein C is modulated by sialic acid on herpes simplex virus type 1-infected cells

Smiley, ML, Friedman, HM

J. Virol. 1985
17984207 Defining targets for complement components C4b and C3b on the pathogenic neisseriae

Lewis, LA, Ram, S, Prasad, A, Gulati, S, Getzlaff, S, Blom, AM, Vogel, U, Rice, PA

Infect. Immun. 2008
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