Proteolytic cleavage of complement factor C4

Stable Identifier
R-GGA-2132233
Type
Reaction [omitted]
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

C4 is cleaved by activated protease C1s in the classical pathway or MASPs in the lectin-mediated pathway producing two fragments C4a and C4b. The larger fragment C4b binds covalently to the target surface due to a highly reactive thioester bond which becomes exposed upon cleavage. Chicken C4 shares 37% amino acid sequence identity with its human counterpart. Correlation between chicken MBL concentration and C4 deposition was observed in chicken sera [Norup LR and Juul-Madsen HR 2007].

The exact cleavage site in chicken C4 is unknown.

Literature References
PubMed ID Title Journal Year
17954581 An assay for measuring the mannan-binding lectin pathway of complement activation in chickens

Norup, LR, Juul-Madsen, HR

Poult Sci 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of C4:factor B activator [plasma membrane]
Physical Entity
Activity
Authored
Reviewed
Created
Cite Us!