Factor H displaces Bb in Cb:Bb complex

Stable Identifier
R-GGA-2132271
Type
Reaction [transition]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
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Factor H accelerates the decay of existing C3/5 convertases by displacing Bb. The events of factor H activity in chicken have not been verified experimentally but are inferred from properties of the orthologous human proteins.
Literature References
PubMed ID Title Journal Year
10779780 Molecular mechanisms of target recognition in an innate immune system: interactions among factor H, C3b, and target in the alternative pathway of human complement

Pangburn, MK, Meri, S, Pangburn, KL, Sharma, AK, Koistinen, V

J. Immunol. 2000
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