Cleavage of C5 by C5 convertases

Stable Identifier
R-GGA-2132278
Type
Reaction [transition]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
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C5 convertases are serine proteases that cleave complement C5 resulting in the formation of two biologically active fragments, C5a and C5b. Both fragments play vital roles in killing microorganisms. The smaller fragment C5a, which is a potent chemotactic agent and anaphylatoxin, mediates inflammatory responses. The larger fragment C5b initiates the formation of the membrane attack complex (MAC) which results in the lysis of the target cell.
Literature References
PubMed ID Title Journal Year
12878586 Formation of high affinity C5 convertase of the classical pathway of complement

Rawal, N, Pangburn, MK

J Biol Chem 2003
16896831 Genomic view of the evolution of the complement system

Nonaka, M, Kimura, A

Immunogenetics 2006
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of C5 convertases [plasma membrane]

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