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Classical antibody-mediated complement activation
Stable Identifier
R-GGA-2132286
Type
Pathway
Species
Gallus gallus
ReviewStatus
5/5
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Innate Immune System (Gallus gallus)
Complement Cascade (Gallus gallus)
Creation of classical C3 convertase (Gallus gallus)
Classical antibody-mediated complement activation (Gallus gallus)
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In mammals, the classical pathway is initiated by binding of antibody molecules (IgM or IgG) to an antigen, followed by binding of complement protein C1q. Two molecules each of C1r and C1s bind to C1q to form an active C1 complex. The activated C1 complex cleaves C4 to generate C4a and C4b. C4b fragment binds the nearby target cell surface. The activated C1 complex then cleaves and activates C2 which has bound to C4b, yielding a C4b:C2a complex (C3 convertase). C3 convertase, in turn, cleaves the third component of complement C3 to form C3a and C3b. A single C3 convertase can generate hundreds molecules of C3b, which can directly bind to the target surface. Opsonization with C3b fragments mark the target cell for phagocytosis. C3b can also bind to the C3 convertase yielding C5 convertase (C4b:C2a:C3b), which cleaves C5 into C5a and C5b. C5b is an active fragment which initiates a membrane attack complex (MAC) formation (Janeway CA et al. 2001).
Literature References
PubMed ID
Title
Journal
Year
Avian Immunology
Davison, F
,
Kaspers, B
,
Schat, KA
2008
Participants
Events
Antigen bound antibody interacts with C1complement complex
(Gallus gallus)
Activation of C1r within the C1complement complex
(Gallus gallus)
C1r activates C1s component within C1 complement complex
(Gallus gallus)
Participates
as an event of
Creation of classical C3 convertase (Gallus gallus)
Event Information
Go Biological Process
complement activation, classical pathway (0006958)
Inferred From
Classical antibody-mediated complement activation (Homo sapiens)
Authored
Shamovsky, V (2012-12-20)
Reviewed
D'Eustachio, P (2012-11-07)
Jupe, S (2013-01-31)
Created
Shamovsky, V (2012-02-21)
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