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MDK [extracellular region]
Stable Identifier
R-GGA-2160953
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
extracellular region
Synonyms
A0A1L1RPU5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Gallus gallus)
Signaling by NOTCH (Gallus gallus)
Signaling by NOTCH2 (Gallus gallus)
NOTCH2 Activation and Transmission of Signal to the Nucleus (Gallus gallus)
NOTCH2 binds MDK (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
MDK:NOTCH2 [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ALK (Gallus gallus)
ALK autophosphorylation (Gallus gallus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Gallus gallus)
ligand-bound ALK dimer [plasma membrane] (Gallus gallus)
MDK:ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
ligand-bound ALK dimer [plasma membrane] (Gallus gallus)
MDK:ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK binds PLCG1 (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK:PLCG1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK binds SHC1 (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK:SHC1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK dimer binds IRS1 (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK:IRS1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK phosphorylates IRS1 (Gallus gallus)
Active ALK:IRS1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK:pY-IRS1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK phosphorylates PLCG1 (Gallus gallus)
Active ALK:PLCG1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK phosphorylates SHC1 (Gallus gallus)
Active ALK:SHC1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK:p-3Y SHC1 [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK recruits PI3K (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Active ALK:PI3K [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
Liganded-ALK dimer binds type I ALK-binding TKIs (Gallus gallus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Gallus gallus)
ligand-bound ALK dimer [plasma membrane] (Gallus gallus)
MDK:ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
ligand-bound ALK dimer [plasma membrane] (Gallus gallus)
MDK:ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
MDK and PTN in ALK signaling (Gallus gallus)
(PTN,MDK):PTPRZ oligomerizes (Gallus gallus)
(PTN,MDK):PTPRZ [plasma membrane] (Gallus gallus)
PTN,MDK [extracellular region] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Gallus gallus)
(PTN,MDK):PTPRZ [plasma membrane] (Gallus gallus)
PTN,MDK [extracellular region] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
ALK binds ligand midkine (MDK) (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
MDK:ALK [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
PTN and MDK bind to PTPRZ (Gallus gallus)
(PTN,MDK):PTPRZ [plasma membrane] (Gallus gallus)
PTN,MDK [extracellular region] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
PTN,MDK [extracellular region] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
PTPRZ dephosphorylates ligand-bound ALK dimers (Gallus gallus)
(PTN,MDK):ALK dimer [plasma membrane] (Gallus gallus)
MDK:ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Gallus gallus)
(PTN,MDK):PTPRZ [plasma membrane] (Gallus gallus)
PTN,MDK [extracellular region] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
(PTN,MDK):p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
PI3K synthesizes PIP3 downstream of ALK (Gallus gallus)
Active ALK:PI3K [plasma membrane] (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
STAT3 is phosphorylated downstream of active ALK (Gallus gallus)
Active ALK dimer [plasma membrane] (Gallus gallus)
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A1L1RPU5
Reference Genes
ENSEMBL:ENSGALG00000008367
UCSC:A0A1L1RPU5
Participates
as a member of
PTN,MDK [extracellular region] (Gallus gallus)
as a component of
MDK:p-7Y ALK dimer [plasma membrane] (Gallus gallus)
MDK:ALK [plasma membrane] (Gallus gallus)
MDK:ALK dimer [plasma membrane] (Gallus gallus)
MDK [extracellular region] (Gallus gallus)
as an input of
ALK binds ligand midkine (MDK) (Gallus gallus)
Inferred From
MDK [extracellular region]
(Homo sapiens)
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