C3a anaphylatoxin binds C3a receptor

Stable Identifier
Reaction [binding]
Gallus gallus
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In mammals, complement C3a receptor (C3aR) is a member of the G protein-coupled receptor family (GPCRs) (Crass T et al. 1996). C3aR is activated upon binding of complement fragments C3a. C3aR transduces signals through multiple pathways, leading to the inhibition of adenylyl cyclase, activation of MAP kinase, phosphoinositol accumulation and calcium mobilization (Sayah S et al. 2003; Ricklin D et al. 2010).

Upon complement activation chicken C3 is cleaved into fragments that resemble mammalian C3a and C3b (Laursen I and Koch C 1989). Chicken C3 and its cleavage products were detected in liver, plasma and different eye tissues (Haynes T et al. 2013). In addition to C3 activation fragments, chicken C3aR mRNA and protein were found in eye tissues at E4 (embryo's stage at which retinectomies are performed). Histological analysis in combination with immuno-histochemical and western blotting procedures using post-retinectomy samples revealed that the treatment with chicken C3a induced chick retina regeneration via MAPK-STAT3 signaling in a C3aR-dependent manner (Haynes T et al. 2013).

Literature References
PubMed ID Title Journal Year
2587932 Purification of chicken C3 and a structural and functional characterization

Laursen, I, Koch, C

Scand J Immunol 1989
12670702 Two different transduction pathways are activated by C3a and C5a anaphylatoxins on astrocytes

Sayah, S, Jauneau, AC, Patte, C, Tonon, MC, Vaudry, H, Fontaine, M

Brain Res Mol Brain Res 2003
8765043 Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells

Crass, T, Raffetseder, U, Martin, U, Grove, M, Klos, A, Köhl, J, Bautsch, W

Eur J Immunol 1996
23942241 Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration

Haynes, T, Luz-Madrigal, A, Reis, ES, Echeverri Ruiz, NP, Grajales-Esquivel, E, Tzekou, A, Tsonis, PA, Lambris, JD, Del Rio-Tsonis, K

Nat Commun 2013
20720586 Complement: a key system for immune surveillance and homeostasis

Ricklin, D, Hajishengallis, G, Yang, K, Lambris, JD

Nat Immunol 2010
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