C5a anaphylatoxin binds C5a receptor

Stable Identifier
Reaction [binding]
Gallus gallus
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In mammals, complement C5a receptor (C5aR) is a member of the G protein-coupled receptor family (GPCRs) (Boulay et al. 1991; Gerard NP and Gerard C 1991). C5aR is activated upon binding of complement fragment C5a. C5aR transduces signals through multiple pathways, leading to the inhibition of adenylyl cyclase, activation of MAP kinase, phosphoinositol accumulation and calcium mobilization [Sayah S et al 2003; Ricklin D et al 2010; Wrann CD et al 2007].

Chicken C5aR mRNA was detected in liver and in various eye tissues (Haynes T et al. 2013). The binding of chicken C5a to C5aR has not been verified experimentally but is inferred from properties of the orthologous human proteins.

Literature References
PubMed ID Title Journal Year
17507002 Distinct involvement of p38-, ERK1/2 and PKC signaling pathways in C5a-mediated priming of oxidative burst in phagocytic cells

Wrann, CD, Winter, SW, Barkhausen, T, Hildebrand, F, Krettek, C, Riedemann, NC

Cell Immunol 2007
2007135 Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells

Boulay, F, Mery, L, Tardif, M, Brouchon, L, Vignais, P

Biochemistry 1991
1847994 The chemotactic receptor for human C5a anaphylatoxin

Gerard, NP, Gerard, C

Nature 1991
12670702 Two different transduction pathways are activated by C3a and C5a anaphylatoxins on astrocytes

Sayah, S, Jauneau, AC, Patte, C, Tonon, MC, Vaudry, H, Fontaine, M

Brain Res Mol Brain Res 2003
23942241 Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration

Haynes, T, Luz-Madrigal, A, Reis, ES, Echeverri Ruiz, NP, Grajales-Esquivel, E, Tzekou, A, Tsonis, PA, Lambris, JD, Del Rio-Tsonis, K

Nat Commun 2013
20720586 Complement: a key system for immune surveillance and homeostasis

Ricklin, D, Hajishengallis, G, Yang, K, Lambris, JD

Nat Immunol 2010
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