CREG (CR1L) causes dissociation of C3 convertases

Stable Identifier
R-GGA-2530591
Type
Reaction [transition]
Species
Gallus gallus
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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CREG (CR1L) causes dissociation of C3 convertases
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CREG has the ability to protect host cells from chicken complement activity [Oshiumi H et al 2005]. CREG is believed to correspond to one long homologous repeat (LHR) of huCR1.

Human CR1 is a potent inhibitor of both the classical and the alternative pathways of complement activation by exhibiting decay-accelerating activity for both C3 and C5 convertases, as well as cofactor activity for factor I-mediated cleavage of C3b and C4b.

Literature References
PubMed ID Title Journal Year
16034113 Regulator of complement activation (RCA) locus in chicken: identification of chicken RCA gene cluster and functional RCA proteins

Hattori, T, Tamaki, Y, Yamada, N, Oshiumi, H, Mizuno, S, Goitsuka, R, Seya, T, Matsumoto, M, Ohba, S, Katoh, J, Shida, K, Kimura, Y, Inoue, N

J. Immunol. 2005
11123320 A novel chicken membrane-associated complement regulatory protein: molecular cloning and functional characterization

Fukui, A, Seya, T, Nishizawa, Y, Inoue, N, Matsumoto, M, Toyoshima, K, Nomura, M

J. Immunol. 2001
Participants
Input
Output
Participates
as an event of
Inferred From
Displacement of C2a/Bb by CR1 (Homo sapiens)
Authored
Shamovsky, V  (2012-12-20)
Reviewed
D'Eustachio, P  (2012-11-07)
Jupe, S  (2013-01-31)
Created
Shamovsky, V  (2012-10-17)
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