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TRAF6 [cytosol]
Stable Identifier
R-GGA-2685681
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
K63polyUb-TRAF6, E1C626
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
TCR signaling (Gallus gallus)
Downstream TCR signaling (Gallus gallus)
Activation of TAK1-TAB2 complex (Gallus gallus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Gallus gallus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-17 signaling (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
Alpha-protein kinase 1 signaling pathway (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
C-type lectin receptors (CLRs) (Gallus gallus)
CLEC7A (Dectin-1) signaling (Gallus gallus)
K63polyUb-TAK1 autophosphorylates (Gallus gallus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-TAK1 [plasma membrane] (Gallus gallus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Gallus gallus)
K63polyUb-TRAF6 oligomer [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TAB1:TAB2/TAB3:K63polyUb-34,158-p3Y,1S-TAK1 [plasma membrane] (Gallus gallus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Gallus gallus)
K63polyUb-TRAF6 oligomer [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
TRIKA2 binds K63polyUb-TRAF6 oligomer (Gallus gallus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Gallus gallus)
K63polyUb-TRAF6 oligomer [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers:TRIKA2 [plasma membrane] (Gallus gallus)
p-T231-CARD9:BCL10:MALT1:K63polyUb-TRAF6 oligomers [plasma membrane] (Gallus gallus)
K63polyUb-TRAF6 oligomer [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated NF-kB activation (Gallus gallus)
Activation of TAK1 complex bound to pUb-TRAF6 (Gallus gallus)
DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Gallus gallus)
DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Gallus gallus)
CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 (Gallus gallus)
DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Gallus gallus)
CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane] (Gallus gallus)
DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6 [plasma membrane] (Gallus gallus)
CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 10 (TLR10) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Toll Like Receptor 3 (TLR3) Cascade (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Gallus gallus)
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex (Gallus gallus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Gallus gallus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Gallus gallus)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Gallus gallus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Activation of TAK1 complex bound to activated TLR4 complex (Gallus gallus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:TAK1complex [endosome membrane] (Gallus gallus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Gallus gallus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Auto ubiquitination of TRAF6 bound to the activated TLR4 complex (Gallus gallus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Phosphorylated TAK1 leaves activated TLR receptor complex (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
activated TLR4:TICAM1:K63pUb-TRAF6:free K63pUb:activated TAK1 complex [endosome membrane] (Gallus gallus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Toll Like Receptor 5 (TLR5) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Gallus gallus)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Gallus gallus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Gallus gallus)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Gallus gallus)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Gallus gallus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated TAK1 phosphorylates MKK4/MKK7 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
activated TAK1 mediates p38 MAPK activation (Gallus gallus)
activated human TAK1 phosphorylates MKK3/MKK6 (Gallus gallus)
Activated TAK complexes [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Deubiquitination (Gallus gallus)
Ovarian tumor domain proteases (Gallus gallus)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Gallus gallus)
OTUD7B,TNFAIP3,ZRANB1:K63polyUb-TRAF6 [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Ub-specific processing proteases (Gallus gallus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Gallus gallus)
CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Gallus gallus)
K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signaling (Gallus gallus)
p75 NTR receptor-mediated signalling (Gallus gallus)
p75NTR signals via NF-kB (Gallus gallus)
p75NTR recruits signalling complexes (Gallus gallus)
TRAF6 is auto-ubiquitinated (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Gallus gallus)
TRAF6 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:E1C626 TRAF6
Gene Names
TRAF6
Reference Genes
BioGPS Gene:423163 TRAF6
ENSEMBL:ENSGALG00010025204.1 TRAF6
KEGG Gene (Gallus gallus):423163 TRAF6
Monarch:423163 TRAF6
NCBI Gene:423163 TRAF6
Reference Transcript
RefSeq:XM_004941545.2 TRAF6
RefSeq:XM_015287208.1 TRAF6
RefSeq:XM_004941547.2 TRAF6
RefSeq:XM_004941548.2 TRAF6
RefSeq:XM_004941546.2 TRAF6
Other Identifiers
423163
GO:0000045
GO:0000122
GO:0000209
GO:0001503
GO:0001843
GO:0002224
GO:0002376
GO:0002637
GO:0002726
GO:0002753
GO:0002755
GO:0003824
GO:0004842
GO:0005164
GO:0005515
GO:0005634
GO:0005737
GO:0005811
GO:0005829
GO:0005886
GO:0005938
GO:0006351
GO:0006355
GO:0006914
GO:0006955
GO:0007155
GO:0007165
GO:0007249
GO:0008270
GO:0009887
GO:0009898
GO:0012501
GO:0016567
GO:0016740
GO:0019886
GO:0023052
GO:0030154
GO:0030316
GO:0031234
GO:0031624
GO:0031625
GO:0031663
GO:0031666
GO:0032481
GO:0032735
GO:0032743
GO:0032755
GO:0032813
GO:0032991
GO:0033209
GO:0034142
GO:0034450
GO:0035556
GO:0035631
GO:0036211
GO:0038061
GO:0038172
GO:0038173
GO:0042088
GO:0042102
GO:0042802
GO:0042826
GO:0042981
GO:0043011
GO:0043122
GO:0043123
GO:0043226
GO:0043422
GO:0045087
GO:0045453
GO:0045672
GO:0045892
GO:0045944
GO:0046849
GO:0046872
GO:0048468
GO:0048471
GO:0048856
GO:0050852
GO:0051865
GO:0061630
GO:0070498
GO:0070534
GO:0070555
GO:0071222
GO:0071345
GO:0097400
GO:0098542
GO:0140096
GO:0140374
GO:1904996
GT_A_87_P018386
GT_A_87_P084486
Gga.14428.1.S1_at
GgaAffx.4973.1.S1_at
GgaAffx.4973.2.S1_s_at
Participates
as a component of
OTUD7B,TNFAIP3,ZRANB1:K63polyUb-TRAF6 [cytosol] (Gallus gallus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Gallus gallus)
hp-IRAK1:3xK63polyUb-TRAF6 [cytosol] (Gallus gallus)
CBM oligomer:oligo-K63-poly Ub-TRAF6 oligomer [plasma membrane] (Gallus gallus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Gallus gallus)
K63-pUb-TRAF6:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Gallus gallus)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Gallus gallus)
K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] (Gallus gallus)
hp-IRAK1:K63polyUb-TRAF6 [cytosol] (Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Gallus gallus)
as a member of
K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Gallus gallus)
as a repeated unit of
K63polyUb-TRAF6 oligomer [cytosol] (Gallus gallus)
Other forms of this molecule
TRAF6 [cytosol]
TRAF6 [cytosol]
TRAF6 [mitochondrial outer membrane]
K63-Ub-TRAF6 [mitochondrial outer membrane]
TRAF6 [plasma membrane]
K63-linked Ub TRAF6 [plasma membrane]
TRAF6 [cytosol]
TRAF6 [endosome membrane]
TRAF6 [endosome membrane]
TRAF6 [endosome membrane]
TRAF6 [plasma membrane]
TRAF6 [plasma membrane]
TRAF6 [cytosol]
Inferred From
K63polyUb-TRAF6 [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 124 (in Homo sapiens)
Coordinate
124
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_004941603.1
,
XP_004941605.1
,
XP_004941604.1
,
XP_015142694.1
,
XP_004941602.1
OpenTargets
ENSG00000175104
Ensembl
ENSGALP00010037979
,
ENSGALT00010061479
,
ENSGALG00010025204
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