glyceraldehyde 3-phosphate + NAD+ + phosphate <=> 1,3-bisphosphoglycerate + NADH + H+

Stable Identifier
R-GGA-352956
Type
Reaction
Species
Gallus gallus
Compartment
Synonyms
Dehydrogenation of glyceraldehyde 3-phosphate to form 1,3-bisphosphoglycerate
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Summation

Cytosolic GAPDH catalyzes the reversible reaction of glyceraldehyde 3-phosphate, NAD+, and phosphate to form 1,3-bisphosphoglycerate and NADH + H+. The active form of the enzyme is a homotetramer (Allison and Kaplan 1964; Dugaiczyk et al. 1983).

Literature References
PubMed ID Title Journal Year
14209940 The comparative enzymology of triophosphate dehydrogenase

Allison, WS, Kaplan, NO

J Biol Chem 1964
6303388 Cloning and sequencing of a deoxyribonucleic acid copy of glyceraldehyde-3-phosphate dehydrogenase messenger ribonucleic acid isolated from chicken muscle

Dugaiczyk, A, Haron, JA, Stone, EM, Dennison, OE, Rothblum, KN, Schwartz, RJ

Biochemistry 1983
Participants
Participant Of
hasEvent
Event Information
Catalyst Activity
Catalyst Activity
Title
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity of GAPDH tetramer [cytosol]
Physical Entity
Activity
Authored
Reviewed