aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate

Stable Identifier
R-GGA-372559
Type
Reaction [transition]
Species
Gallus gallus
Compartment
mitochondrial matrix
Synonyms
Transamination of aspartate and alpha-ketoglutarate (2-oxoglutarate) to form oxaloacetate and glutamate
ReviewStatus
5/5
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aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate
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Mitochondrial GOT2 catalyzes the reversible transamination of aspartate and alpha-ketoglutarate (2-oxoglutarate) to form oxaloacetate and glutamate. The acrtive form of the enzyme is a homodimer, with one molecule of pyridoxal phosphate bound to each enzyme monomer (McPhalen et al. 1992).
Literature References
PubMed ID Title Journal Year
1593633 X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase

Vincent, MG, Jansonius, JN, McPhalen, CA

J Mol Biol 1992
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Event Information
Reverse Reaction
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)
Catalyst Activity

L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]

Physical Entity
GOT2 dimer [mitochondrial matrix] (Gallus gallus)
Activity
L-aspartate:2-oxoglutarate aminotransferase activity (GO:0004069)
Authored
D'Eustachio, P  (2008-09-10)
Reviewed
Harris, RA  (2008-09-10)
Created
D'Eustachio, P  (2008-06-27)
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