aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate

Stable Identifier
R-GGA-372559
Type
Reaction [transition]
Species
Gallus gallus
Compartment
Synonyms
Transamination of aspartate and alpha-ketoglutarate (2-oxoglutarate) to form oxaloacetate and glutamate
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Mitochondrial GOT2 catalyzes the reversible transamination of aspartate and alpha-ketoglutarate (2-oxoglutarate) to form oxaloacetate and glutamate. The acrtive form of the enzyme is a homodimer, with one molecule of pyridoxal phosphate bound to each enzyme monomer (McPhalen et al. 1992).

Literature References
PubMed ID Title Journal Year
1593633 X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase

McPhalen, CA, Vincent, MG, Jansonius, JN

J Mol Biol 1992
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]
Physical Entity
Activity
Authored
Reviewed
Created