oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate)

Stable Identifier
R-GGA-372564
Type
Reaction [transition]
Species
Gallus gallus
Compartment
mitochondrial matrix
Synonyms
Transamination of oxaloacetate and glutamate to form aspartate and alpha-ketoglutarate (2-oxoglutarate)
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mitochondrial GOT2 catalyzes the reversible transamination of oxaloacetate and glutamate to form aspartate and alpha-ketoglutarate (2-oxoglutarate). The active form of the enzyme is a homodimer, with one molecule of pyridoxal phosphate bound to each enzyme monomer (Graf-Hausner et al. 1983; McPhalen et al. 1992).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Event Information
Reverse Reaction
aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)
Catalyst Activity
Catalyst Activity
Title
L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]
Physical Entity
GOT2 dimer [mitochondrial matrix]
Activity
L-aspartate:2-oxoglutarate aminotransferase activity (0004069)
Authored
D'Eustachio, P  (2008-09-11)
Reviewed
Harris, RA  (2008-09-10)
Created
D'Eustachio, P  (2008-06-27)