oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate)

Stable Identifier
R-GGA-372564
Type
Reaction [transition]
Species
Gallus gallus
Compartment
mitochondrial matrix
Synonyms
Transamination of oxaloacetate and glutamate to form aspartate and alpha-ketoglutarate (2-oxoglutarate)
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oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate)
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Mitochondrial GOT2 catalyzes the reversible transamination of oxaloacetate and glutamate to form aspartate and alpha-ketoglutarate (2-oxoglutarate). The active form of the enzyme is a homodimer, with one molecule of pyridoxal phosphate bound to each enzyme monomer (Graf-Hausner et al. 1983; McPhalen et al. 1992).

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Event Information
Reverse Reaction
aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)
Catalyst Activity

L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]

Physical Entity
GOT2 dimer [mitochondrial matrix] (Gallus gallus)
Activity
L-aspartate:2-oxoglutarate aminotransferase activity (GO:0004069)
Authored
D'Eustachio, P  (2008-09-10)
Reviewed
Harris, RA  (2008-09-10)
Created
D'Eustachio, P  (2008-06-27)
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