Mitochondrial GOT2 catalyzes the reversible transamination of oxaloacetate and glutamate to form aspartate and alpha-ketoglutarate (2-oxoglutarate). The active form of the enzyme is a homodimer, with one molecule of pyridoxal phosphate bound to each enzyme monomer (Graf-Hausner et al. 1983; McPhalen et al. 1992).
McPhalen, CA, Vincent, MG, Jansonius, JN
Graf-Hausner, U, Wilson, KJ, Christen, P
L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]
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