oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate)

Stable Identifier
R-GGA-372717
Type
Reaction [transition]
Species
Gallus gallus
Compartment
Synonyms
Transamination of oxaloacetate and glutamate to form aspartate and alpha-ketoglutarate (2-oxoglutarate)
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic GOT1 catalyzes the reversible transamination of oxaloacetate and glutamate to form aspartate and alpha-ketoglutarate (2-oxoglutarate). The active form of the enzyme is a homodimer, with one molecule of pyridoxal phosphate bound to each enzyme monomer (Shlyapnikov et al. 1979).

Literature References
PubMed ID Title Journal Year
499525 Primary structure of cytoplasmic aspartate aminotransferase from chicken heart and its homology with pig heart isoenzymes

Shlyapnikov, SV, Myasnikov, AN, Severin, ES, Myagkova, MA, Torchinsky, YM, Braunstein, AE

FEBS Lett 1979
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
L-aspartate:2-oxoglutarate aminotransferase activity of GOT1 dimer [cytosol]
Physical Entity
Activity
Authored
Reviewed
Created