aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate

Stable Identifier
R-GGA-372719
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
Synonyms
Transamination of aspartate and alpha-ketoglutarate (2-oxoglutarate) to form oxaloacetate + glutamate
ReviewStatus
5/5
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aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate
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Cytosolic GOT1 catalyzes the reversible transamination of aspartate and alpha-ketoglutarate (2-oxoglutarate) to form oxaloacetate and glutamate. The active form of the enzyme is a homodimer, with one molecule of pyridoxal phosphate bound to each enzyme monomer (Shlyapnikov et al. 1979).
Literature References
PubMed ID Title Journal Year
499525 Primary structure of cytoplasmic aspartate aminotransferase from chicken heart and its homology with pig heart isoenzymes

Shlyapnikov, SV, Myasnikov, AN, Severin, ES, Myagkova, MA, Torchinsky, YM, Braunstein, AE

FEBS Lett 1979
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Catalyst Activity

L-aspartate:2-oxoglutarate aminotransferase activity of GOT1 dimer [cytosol]

Physical Entity
GOT1 dimer [cytosol] (Gallus gallus)
Activity
L-aspartate:2-oxoglutarate aminotransferase activity (GO:0004069)
Authored
D'Eustachio, P  (2008-09-10)
Reviewed
Harris, RA  (2008-09-10)
Created
D'Eustachio, P  (2008-06-28)
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