oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]

Stable Identifier
R-GGA-372724
Type
Reaction [transition]
Species
Gallus gallus
Compartment
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PCK2, the mitochondrial matrix form of phosphoenopyruvate carboxykinase, catalyzes the reaction of oxaloacetate and GTP to form phosphoenolpyruvate, GDP, and CO2. In the chicken, PCK2 is constitutively expressed in liver, where it is the only form of the enzyme, and kidney, where cytosolic PCK1 is also expressed (Kurahashi et al. 1957; Hod et al. 1982; Weldon et al. 1990).

Literature References
PubMed ID Title Journal Year
13438893 Nucleotide specificity of oxalacetic carboxylase

Kurahashi, K, Pennington, RJ, Utter, MF

J Biol Chem 1957
7142177 The mitochondrial and cytosolic forms of avian phosphoenolpyruvate carboxykinase (GTP) are encoded by different messenger RNAs

Hod, Y, Utter, MF, Hanson, RW

J Biol Chem 1982
2110163 Mitochondrial phosphoenolpyruvate carboxykinase from the chicken. Comparison of the cDNA and protein sequences with the cytosolic isozyme

Weldon, SL, Rando, A, Matathias, AS, Hod, Y, Kalonick, PA, Savon, S, Cook, JS, Hanson, RW

J Biol Chem 1990
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Catalyst Activity
Catalyst Activity
Title
phosphoenolpyruvate carboxykinase (GTP) activity of PCK2 [mitochondrial matrix]
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