2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]

Stable Identifier
R-GGA-372742
Type
Reaction [transition]
Species
Gallus gallus
Compartment
mitochondrial matrix, mitochondrial inner membrane, cytosol
Synonyms
Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
ReviewStatus
5/5
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2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]
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SLC25A21, the mitochondrial 2-oxodicarboxylate carrier, mediates the exchange of 2-oxoadipate and 2-oxoglutarate across the inner mitochondrial membrane. No chicken transport protein capable of mediating this reaction has been identified, although an open reading frame capable of encoding a protein closely similar to authentic human SLC25A21 has been identified computationally in the ENSEMBL chicken gene set. This reaction is inferred from its human counterpart.
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Catalyst Activity

alpha-ketoglutarate transmembrane transporter activity of SLC25A21 [mitochondrial inner membrane]

Physical Entity
SLC25A21 [mitochondrial inner membrane] (Gallus gallus)
Activity
alpha-ketoglutarate transmembrane transporter activity (GO:0015139)
Inferred From
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Homo sapiens)
Authored
D'Eustachio, P  (2008-09-10)
Created
D'Eustachio, P  (2008-06-28)
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