isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+

Stable Identifier
R-GGA-373024
Type
Reaction [transition]
Species
Gallus gallus
Compartment
mitochondrial matrix
ReviewStatus
5/5
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isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+
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Mitochondrial isocitrate dehydrogenase (IDH3-like) catalyzes the reaction of isocitrate and NAD+ to form 2-oxoglutarate (alpha-ketoglutarate), CO2, and NADH + H+. No chicken enzyme capable of catalyzing this reaction has been identified, although an open reading frame capable of encoding a protein closely similar to authentic human mitochondrial isocitrate dehydrogenase (IDH3) has been identified computationally in the ENSEMBL chicken gene set. This reaction is inferred from its human counterpart.
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Catalyst Activity

isocitrate dehydrogenase (NAD+) activity of IDH3-like [mitochondrial matrix]

Physical Entity
IDH3-like [mitochondrial matrix] (Gallus gallus)
Activity
isocitrate dehydrogenase (NAD+) activity (GO:0004449)
Inferred From
IDH3 complex decarboxylates isocitrate (Homo sapiens)
Authored
D'Eustachio, P  (2008-09-10)
Created
D'Eustachio, P  (2008-07-11)
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