Reactome: A Curated Pathway Database

isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+

Stable Identifier
R-GGA-373024
Type
Reaction
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
Summation

Mitochondrial isocitrate dehydrogenase (IDH3-like) catalyzes the reaction of isocitrate and NAD+ to form 2-oxoglutarate (alpha-ketoglutarate), CO2, and NADH + H+. No chicken enzyme capable of catalyzing this reaction has been identified, although an open reading frame capable of encoding a protein closely similar to authentic human mitochondrial isocitrate dehydrogenase (IDH3) has been identified computationally in the ENSEMBL chicken gene set. This reaction is inferred from its human counterpart.

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
isocitrate dehydrogenase (NAD+) activity of IDH3-like [mitochondrial matrix] IDH3-like [mitochondrial matrix] isocitrate dehydrogenase (NAD+) activity (0004449)
Inferred From