Reactome: A Curated Pathway Database

2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+

Stable Identifier
R-GGA-373042
Type
Reaction
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
Summation

Mitochondrial 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase complex catalyzes the reaction of 2-oxoglutarate, CoASH, and NAD+ to form succinylCoA, CO2, and NADH + H+. No chicken enzyme complex capable of catalyzing this reaction has been identified, although open reading frames capable of encoding proteins closely similar to each of the three authentic human 2-oxoglutarate dehydrogenase E1, E2, and E3 subunits have been identified computationally in the ENSEMBL chicken gene set. This reaction is inferred from its human counterpart.

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
oxoglutarate dehydrogenase (NAD+) activity of 2-oxoglutarate dehydrogenase complex [mitochondrial matrix] 2-oxoglutarate dehydrogenase complex [mitochondrial matrix] oxoglutarate dehydrogenase (NAD+) activity (0034602)
Inferred From