Reactome: A Curated Pathway Database

succinate + FAD <=> fumarate + FADH2

Stable Identifier
R-GGA-373147
Type
Reaction
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
Summation

The SDH (succinate dehydrogenase) complex, embedded in the inner mitochondrial membrane, catalyzes the reversible oxidation of succinate to fumarate, coupled to the reduction of SDH-associated FAD to FADH2. No chicken enzyme capable of catalyzing this reaction has been characterized, although open reading frames capable of encoding three of the four proteins predicted from characterization of authentic human mitochondrial succinate dehydrogenase has been identified computationally in the ENSEMBL chicken gene set or in large-scale screens of cDNA clones. This reaction is inferred from its human counterpart.

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
succinate dehydrogenase (ubiquinone) activity of SDH complex [mitochondrial inner membrane] SDH complex [mitochondrial inner membrane] succinate dehydrogenase (ubiquinone) activity (0008177)
Inferred From