Reactome | NDE1 [cytosol]

NDE1 [cytosol]

Stable Identifier

R-GGA-376257

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

NDE1, Q5ZMC9

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Gallus gallus)

- Cilium Assembly (Gallus gallus)
  - Anchoring of the basal body to the plasma membrane (Gallus gallus)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Gallus gallus)
      - basal body:transition zone proteins [cytosol] (Gallus gallus)
        
        basal body [cytosol] (Gallus gallus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Gallus gallus)
        
        NDE1 [cytosol] (Gallus gallus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Gallus gallus)
        
        basal body:transition zone proteins [cytosol] (Gallus gallus)
        
        basal body [cytosol] (Gallus gallus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Gallus gallus)
        
        NDE1 [cytosol] (Gallus gallus)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Gallus gallus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Gallus gallus)
        
        basal body:transition zone proteins [cytosol] (Gallus gallus)
        
        basal body [cytosol] (Gallus gallus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Gallus gallus)
        
        NDE1 [cytosol] (Gallus gallus)
    - Recruitment of transition zone proteins (Gallus gallus)
      - basal body [cytosol] (Gallus gallus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Gallus gallus)
        
        NDE1 [cytosol] (Gallus gallus)
      - basal body:transition zone proteins [cytosol] (Gallus gallus)
        
        basal body [cytosol] (Gallus gallus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Gallus gallus)
        
        NDE1 [cytosol] (Gallus gallus)
    - The distal appendage proteins recruit TTBK2 (Gallus gallus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Gallus gallus)
        
        mother centriole:C2CD3 [cytosol] (Gallus gallus)
        
        mother centriole [cytosol] (Gallus gallus)
        
        NDE1 [cytosol] (Gallus gallus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Gallus gallus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Gallus gallus)
        
        mother centriole:C2CD3 [cytosol] (Gallus gallus)
        
        mother centriole [cytosol] (Gallus gallus)
        
        NDE1 [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
  - Signaling by Rho GTPases (Gallus gallus)
    - RHO GTPase Effectors (Gallus gallus)
      - RHO GTPases Activate Formins (Gallus gallus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Gallus gallus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        NDE1 [cytosol] (Gallus gallus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Gallus gallus)
        
        Kinetochore [cytosol] (Gallus gallus)
        
        NDE1 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q5ZMC9

Gene Names

NDE1

Reference Genes

BioGPS Gene:416597 NDE1

ENSEMBL:ENSGALG00000032590

ENSEMBL:ENSGALG00010020635.1 NDE1

ENSEMBL:ENSGALG00015024672 NDE1

KEGG Gene (Gallus gallus):416597 NDE1

Monarch:416597 NDE1

NCBI Gene:416597 NDE1

Reference Transcript

RefSeq:NM_001006169.1 NDE1

Other Identifiers

416597

GO:0000132

GO:0000278

GO:0000776

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005856

GO:0005871

GO:0005874

GO:0007010

GO:0007018

GO:0007020

GO:0007049

GO:0007059

GO:0007100

GO:0007163

GO:0008017

GO:0008092

GO:0016477

GO:0031616

GO:0043226

GO:0047496

GO:0048870

GO:0051298

GO:0051301

GO:0051303

GO:0051642

GO:0065003

GO:0140014

GT_A_87_P037078

GgaAffx.11558.1.S1_s_at

Participates

as a component of

Inferred From

NDE1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001006169.1

OpenTargets

ENSG00000072864

Ensembl

ENSGALP00010029432, ENSGALT00010049815, ENSGALG00010020635

PRO

Q5ZMC9

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