2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix]

Stable Identifier
R-GGA-376887
Type
Reaction [transition]
Species
Gallus gallus
Compartment
Synonyms
Exchange of cytosolic malate for mitochondrial 2-oxoglutarate
Locations in the PathwayBrowser
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The exchange of cytosolic malate for mitochondrial 2-oxoglutarate (alpha-ketoglutarate) mediated by the transport protein SLC25A11 is well-studied in humans, and this exchange reaction, a key part of glucose, lipid, and amino acid metabolism seems likely to occur in chickens. OrthoMCL analysis of genomic sequences indicates that SLC25A11 is well-conserved over diverse species, but no chicken ortholog of the gene has yet been detected. This reaction is thus inferred on the hypothesis that the lack of a chicken SLC25A11 ortholog represents a gap in the chicken genomic sequence.

Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
oxoglutarate:malate antiporter activity of hypothetical 2-oxoglutarate/malate carrier protein [mitochondrial inner membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created