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phospho-p-Y419-SRC [cytosol]
Stable Identifier
R-GGA-377592
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
P00523
Locations in the PathwayBrowser
Expand all
Cell Cycle (Gallus gallus)
Cell Cycle, Mitotic (Gallus gallus)
Mitotic G1 phase and G1/S transition (Gallus gallus)
G1 Phase (Gallus gallus)
Cyclin D associated events in G1 (Gallus gallus)
Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Gallus gallus)
(p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2) [cytosol] (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
GP1b-IX-V activation signalling (Gallus gallus)
GP1b signaling involves c-Src (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
c-Src binds Raf1 (Gallus gallus)
Active c-Src:Raf1 [cytosol] (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
Platelet Aggregation (Plug Formation) (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of SRC (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
Phosphorylation of pPTK2 by SRC (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
SYK activation by SRC (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
Signal amplification (Gallus gallus)
ADP signalling through P2Y purinoceptor 1 (Gallus gallus)
Src activation following P2Y purinoceptor activation (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Integrin signaling (Gallus gallus)
Autophosphorylation of SRC (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
Phosphorylation of pPTK2 by SRC (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
SYK activation by SRC (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by VEGF (Gallus gallus)
VEGFA-VEGFR2 Pathway (Gallus gallus)
AXL autophosphorylates on Y779 and Y821 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
Phosphorylation of SRC-1 (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
SRC-1 phosphorylates SHB (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
VEGFR2 mediated cell proliferation (Gallus gallus)
SFKs phosphorylate PLCG1 (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
p-AXL binds PI3K (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Gallus gallus)
phospho-p-Y419-SRC [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:P00523 SRC
Gene Names
SRC
Chain
initiator methionine:, chain:2-533
Reference Genes
BioGPS Gene:396442 SRC
KEGG Gene (Gallus gallus):396442 SRC
Monarch:396442 SRC
NCBI Gene:396442 SRC
Reference Transcript
RefSeq:XM_015296348.1 SRC
RefSeq:NM_205457.2 SRC
Participates
as an output of
Src activation following P2Y purinoceptor activation (Gallus gallus)
GP1b signaling involves c-Src (Gallus gallus)
as an input of
c-Src binds Raf1 (Gallus gallus)
as a component of
Active c-Src:Raf1 [cytosol] (Gallus gallus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Gallus gallus)
as a candidate of
(p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2) [cytosol] (Gallus gallus)
Other forms of this molecule
SRC [cytosol]
phospho-p-Y419-SRC [cytosol]
MyrG-SRC [plasma membrane]
Src [cytosol]
SRC-1 [plasma membrane]
phospho-MyrG,p-Y530-SRC [plasma membrane]
phospho-MyrG-p-Y419-SRC [plasma membrane]
SRC-2 [cytosol]
Inferred From
p-Y419-SRC [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 419 (in Homo sapiens)
Coordinate
419
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_015151834.1
,
NP_990788.2
ZINC - Investigational
SRC_CHICK
ZINC - World Drugs
SRC_CHICK
OpenTargets
ENSG00000197122
ZINC - FDA approved
SRC_CHICK
ZINC - Substances
SRC_CHICK
ZINC target
P00523
PRO
P00523
ZINC - Predictions - Purchasable
SRC_CHICK
PDB
7AH3
,
7PVZ
,
2HWP
,
1NLO
,
1PRM
,
3EN5
,
7A3C
,
7A3A
,
4MCV
,
7PVX
,
4HVU
,
4OMM
,
7PVW
,
5D10
,
5XP5
,
3G5D
,
7A32
,
5SWH
,
3EN6
,
5K9I
,
4LE9
,
3EN7
,
5D11
,
7A3E
,
6L8L
,
3U4W
,
2OIQ
,
7A35
,
3UQG
,
1RLQ
,
4RTV
,
3G6G
,
4RTX
,
5OB2
,
5OAV
,
7A36
,
1NLP
,
7A3B
,
3QLF
,
3F3W
,
7WF5
,
2QQ7
,
3TZ9
,
7A31
,
4DGG
,
3DQW
,
6XVO
,
4OMP
,
1P13
,
3SVV
,
3DQX
,
7NES
,
5OB0
,
6HVF
,
3D7U
,
5J5S
,
5BMM
,
6XX5
,
6XX3
,
6WIW
,
2PTK
,
7A39
,
2HWO
,
4QT7
,
4RTZ
,
7A3D
,
3TZ7
,
3FJ5
,
7PVY
,
7D57
,
4U5J
,
4O2P
,
1PRL
,
7PW0
,
2QLQ
,
4OML
,
2QI8
,
4RTU
,
3QLG
,
3UQF
,
3TZ8
,
7A30
,
4HVV
,
5D12
,
5EC7
,
3U51
,
4FIC
,
4HVW
,
4OMN
,
4YBJ
,
7A34
,
4OMQ
,
5SYS
,
4LGG
,
6HVE
,
1RLP
,
3F3T
,
3F6X
,
4LGH
,
7A37
,
4RTW
,
3F3U
,
6XVN
,
3EN4
,
5XP7
,
4RTY
,
1F1W
,
6XVM
,
5I11
,
4JZ4
,
3F3V
,
7A33
,
3LOK
,
1SRM
,
4OMO
,
3GEQ
,
7NET
,
4AGW
,
5OB1
,
3D7T
,
7NER
,
3EL7
,
7D5O
,
1SRL
,
6XX4
,
3OF0
,
4YBK
,
5TEH
,
7A38
,
3EL8
,
5ECA
,
6XX2
,
1F2F
,
4JZ3
,
3G6H
,
3OEZ
,
5T0P
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41240 CSK
2
CSK [plasma membrane]
(R-HSA-180499)
CSK [cytosol]
(R-HSA-203776)
0.719
7
UniProt:P18433 PTPRA
1
PTPRA [plasma membrane]
(R-HSA-388755)
0.59
4
UniProt:Q00944
11
phospho-pY-PTK2 [cytosol]
(R-GGA-9632393)
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-GGA-8874613)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-GGA-8874600)
phospho-p-5Y-PTK2 [cytosol]
(R-GGA-5218711)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-GGA-5229006)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-GGA-5218694)
PTK2(773-1052) [cytosol]
(R-GGA-202829)
PTK2(1-772) [cytosol]
(R-GGA-202827)
PTK2 [cytosol]
(R-GGA-201621)
phospho-p-Y397-PTK2 [cytosol]
(R-GGA-354068)
phospho-p-6Y-PTK2 [cytosol]
(R-GGA-354128)
0.589
3
UniProt:O88703
1
HCN2 [plasma membrane]
(R-MMU-977502)
0.581
5
UniProt:Q9QWY8-1 ASAP1
0.581
3
UniProt:Q90738 AFAP1
0.564
3
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.564
2
UniProt:Q9Y4D1 DAAM1
1
DAAM1 [cytosol]
(R-HSA-351052)
0.556
3
UniProt:Q9QWY8-2 ASAP1
0.544
2
UniProt:P61980
2
Hnrnpk [nucleoplasm]
(R-RNO-4570532)
Hnrnpk [nucleoplasm]
(R-RNO-71945)
0.544
2
UniProt:P18052
1
PTPRA [plasma membrane]
(R-MMU-388755)
0.525
2
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