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VHL [cytosol]
Stable Identifier
R-GGA-391423
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
R4GLJ6
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to hypoxia (Gallus gallus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Gallus gallus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Gallus gallus)
VHL [cytosol] (Gallus gallus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Gallus gallus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Gallus gallus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Class I MHC mediated antigen processing & presentation (Gallus gallus)
Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
Polyubiquitination of substrate (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
E3:Ub:substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
Release of E3 from polyubiquitinated substrate (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
E3:Ub:substrate [cytosol] (Gallus gallus)
E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
Metabolism of proteins (Gallus gallus)
Post-translational protein modification (Gallus gallus)
Neddylation (Gallus gallus)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Gallus gallus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
CRL2 E3 ubiquitin ligase [cytosol] (Gallus gallus)
CUL2-box protein [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
NEDD8-CRL2 E3 ligase complex [cytosol] (Gallus gallus)
CUL2-box protein [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Gallus gallus)
CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
CRL2 E3 ubiquitin ligase [cytosol] (Gallus gallus)
CUL2-box protein [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
CRL2 E3 ubiquitin ligase [cytosol] (Gallus gallus)
CUL2-box protein [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Gallus gallus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
CRL2 E3 ubiquitin ligase [cytosol] (Gallus gallus)
CUL2-box protein [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
NEDD8-CRL2 E3 ligase complex [cytosol] (Gallus gallus)
CUL2-box protein [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Gallus gallus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Gallus gallus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Gallus gallus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Gallus gallus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Gallus gallus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Gallus gallus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Gallus gallus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Gallus gallus)
VBC complex [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
RHOBTB3 ATPase cycle (Gallus gallus)
RHOBTB3 binds interacting proteins at trans-Golgi network (Gallus gallus)
RHOBTB3 interacting proteins [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Gallus gallus)
RHOBTB3 interacting proteins [cytosol] (Gallus gallus)
VHL [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:R4GLJ6
Reference Genes
ENSEMBL:ENSGALG00000028009
Participates
as a member of
RHOBTB3 interacting proteins [cytosol] (Gallus gallus)
CUL2-box protein [cytosol] (Gallus gallus)
as a component of
VBC complex [cytosol] (Gallus gallus)
Other forms of this molecule
monoSUMO1-K159,171,196-VHL [nucleoplasm]
VHL [nucleoplasm]
Inferred From
VHL [cytosol]
(Homo sapiens)
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