Elongation and translocation of the extended telomeric chromosome end

Stable Identifier
R-GGA-417127
Type
Reaction [transition]
Species
Gallus gallus
Compartment
Synonyms
telomerase RNP:G-strand complex with one added single-stranded repeat + dNTP => telomerase RNP:G-strand complex with two added single-stranded repeats + pyrophosphate
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TERC directs the sequential addition of nucleotides to the 3' end of a chromosomal DNA strand with one added telomere repeat. After each addition, the template must move relative to the telomerase active site to bring the next template residue into the active site. The product of these additions and translocations is a chromosomal single-stranded end extended by two repeat units (each complementary to the TERC template sequence), positioned on the template so as to allow repetition of the process. The template region of TERC is perfectly conserved between humans and chickens (Chen et al. 2000). The molecular details of the process have been studied in humans; the orthologous chicken event is inferred from those data.

Literature References
PubMed ID Title Journal Year
10721988 Secondary structure of vertebrate telomerase RNA

Chen, JL, Blasco, MA, Greider, CW

Cell 2000
Participants
Participates
Catalyst Activity

telomerase activity of telomerase RNP:G-strand complex with one added single-stranded repeat [nucleoplasm]

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