Reactome | 5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)

5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)

Stable Identifier

R-GGA-419214

Type

Reaction [transition]

Species

Gallus gallus

Compartment

cytosol

ReviewStatus

5/5

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5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)

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The phosphoribosylaminoimidazole carboxylase activity of cytosolic PAICS (multifunctional protein ADE2) catalyzes the reaction of 5'-phosphoribosyl-5-aminoimidazole (AIR) and CO2 to form 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR). Chicken PAICS protein has been purified and its catalytic properties analyzed in vitro. Its aminoterminus is modified by deletion of the first two residues encoded by the PAICS gene (Firestine and Davisson 1994; Firestine et al. 1994). The native chicken protein behaves as a large multimer on gel filtration; it is inferred to be a octamer by analogy to the human protein (Li et al. 2007). The subcellular location of the chicken enzyme is inferred from that of its better-characterized mammalian counterparts.

Literature References

PubMed ID	Title	Journal	Year
2147474	De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli Qiu, H, Zalkin, H, Aimi, J, Williams, J, Dixon, JE	Nucleic Acids Res	1990
7918411	Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms Mueller, EJ, Firestine, SM, Stubbe, J, Poon, SW, Davisson, VJ	Biochemistry	1994
17224163	Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis Xie, XC, Wang, QH, Tong, YP, Li, SX, Li, SG, Zhang, ZY, Bi, RC, Zhou, HN, Zhang, XC, Gao, W, Han, Y	J Mol Biol	2007

Participants

Input

Output

CAIR [cytosol]

Participates

as an event of

De novo synthesis of IMP (Gallus gallus)

Catalyst Activity

phosphoribosylaminoimidazole carboxylase activity of PAICS octamer [cytosol]

Physical Entity

PAICS octamer [cytosol] (Gallus gallus)

Activity

phosphoribosylaminoimidazole carboxylase activity (GO:0004638)

Authored

D'Eustachio, P (2009-04-29)

Created

D'Eustachio, P (2009-04-29)

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