uroporphyrinogen III => coproporphyrinogen III + 4 CO2

Stable Identifier
R-GGA-421515
Type
Reaction [transition]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
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Cytosolic UROD (uroporphyrinogen decarboxylase) catalyzes the reaction of uroporphyrinogen III to form coproporphyrinogen III and four molecules of CO2. Chicken UROD is known only as the inferred product of a gene discovered by analysis of the chicken genomic DNA sequence. Its dimerization to form an active enzyme and its catalytic activity are inferred from the properties of its better-studied human counterpart.
Literature References
PubMed ID Title Journal Year
17360334 A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda

Kushner, JP, Phillips, JD, Reilly, CA, Bergonia, HA, Franklin, MR

Proc. Natl. Acad. Sci. U.S.A. 2007
  The Metabolic and Molecular Bases of Inherited Diseases

Valle, D

  2001
Participants
Participates
Catalyst Activity

uroporphyrinogen decarboxylase activity of UROD dimer [cytosol]

Inferred From
Authored
Created
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