uroporphyrinogen III => coproporphyrinogen III + 4 CO2

Stable Identifier
R-GGA-421515
Type
Reaction [transition]
Species
Gallus gallus
Compartment
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Cytosolic UROD (uroporphyrinogen decarboxylase) catalyzes the reaction of uroporphyrinogen III to form coproporphyrinogen III and four molecules of CO2. Chicken UROD is known only as the inferred product of a gene discovered by analysis of the chicken genomic DNA sequence. Its dimerization to form an active enzyme and its catalytic activity are inferred from the properties of its better-studied human counterpart.

Literature References
PubMed ID Title Journal Year
  The Metabolic and Molecular Bases of Inherited Diseases

Valle, D

  2001
17360334 A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda

Phillips, JD, Bergonia, HA, Reilly, CA, Franklin, MR, Kushner, JP

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
uroporphyrinogen decarboxylase activity of UROD dimer [cytosol]
Physical Entity
Activity
Inferred From
Authored
Created