3-dehydrosphinganine + NADPH + H+ => sphinganine + NADP+

Stable Identifier
R-GGA-433576
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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3-dehydrosphinganine + NADPH + H+ => sphinganine + NADP+
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KDSR (3-ketodihydrosphingosine reductase) enzyme associated with the cytosolic face of the endoplasmic reticulum membrane catalyzes the reduction of 3-dehydrosphinganine by NADPH to form sphinganine (dihydrosphingosine). Chicken KDSR is known only as the predicted product of a cDNA identified in a high-throughput experiment. This reaction is inferred from its well-studied human counterpart.
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Catalyst Activity

3-dehydrosphinganine reductase activity of KDSR [endoplasmic reticulum membrane]

Physical Entity
KDSR [endoplasmic reticulum membrane] (Gallus gallus)
Activity
3-dehydrosphinganine reductase activity (GO:0047560)
Inferred From
KDSR reduces 3-ketosphingoid (Homo sapiens)
Created
D'Eustachio, P  (2009-08-22)
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