dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O

Stable Identifier
R-GGA-433593
Type
Reaction [transition]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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DEGS2 (sphingolipid C4-hydroxylase 2 / degenerative spermatocyte homolog 2) enzyme associated with the cytosolic face of the endoplasmic reticulum catalyzes the hydroxylation of dihydroceramide to form phytoceramide. Chicken DEGS2 is known only as the inferred protein product of an open reading frame identified by analysis of the chicken genome. This reaction is inferred from its well-studied mammalian counterpart.
Participants
Participates
Catalyst Activity

sphingosine hydroxylase activity of DEGS2 [endoplasmic reticulum membrane]

Inferred From
Created
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