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dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O
Stable Identifier
R-GGA-433593
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
,
endoplasmic reticulum membrane
ReviewStatus
5/5
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Metabolism (Gallus gallus)
Lipid metabolism (Gallus gallus)
Sphingolipid metabolism (Gallus gallus)
dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O (Gallus gallus)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
DEGS2 (sphingolipid C4-hydroxylase 2 / degenerative spermatocyte homolog 2) enzyme associated with the cytosolic face of the endoplasmic reticulum catalyzes the hydroxylation of dihydroceramide to form phytoceramide. Chicken DEGS2 is known only as the inferred protein product of an open reading frame identified by analysis of the chicken genome. This reaction is inferred from its well-studied mammalian counterpart.
Participants
Input
DHCE [endoplasmic reticulum membrane]
H+ [cytosol]
NADPH [cytosol]
O2 [cytosol]
Output
H2O [cytosol]
NADP+ [cytosol]
phytoceramide [endoplasmic reticulum membrane]
Participates
as an event of
Sphingolipid metabolism (Gallus gallus)
Catalyst Activity
sphingosine hydroxylase activity of DEGS2 [endoplasmic reticulum membrane]
Physical Entity
DEGS2 [endoplasmic reticulum membrane]
(Gallus gallus)
Activity
sphingosine hydroxylase activity (GO:0000170)
Inferred From
DEGS2 oxygenates dihydroceramide (Homo sapiens)
Created
D'Eustachio, P (2009-08-22)
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