viral dsRNA : TRL3 recruits TICAM1

Stable Identifier
Reaction [binding]
Gallus gallus
Related Species
Infectious bronchitis virus
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Chicken TICAM1 encodes a 735 amino-acid protein that shares 31% sequence identity with its human and mouse orthologs.

TICAM1 (or TRIF) is known to be an essential and exclusive adaptor used by TLR3 ; all the poly(I:C)-induced pathways leading to NFkB and IRF3 activation were abolished in TRIF–/– mice (Yamamoto et al. 2003).

Human TICAM1 consists of an N-terminal region (1–234), a TIR domain (235–500), and a C-terminal region (501–680).

The N-terminal region of TICAM1 harbors TRAF (TNF receptor associated factor) family proteins and forms complexes containing IRF-3 and/or NFkB -activating kinases.

The C-terminal region of TICAM1 can recruit receptor-interacting protein-1 (RIP-1), and this event is followed by the activation of IKK complex .

Literature References
PubMed ID Title Journal Year
12855817 Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

Sugiyama, M, Takeuchi, O, Sanjo, H, Hoshino, K, Takeda, K, Okabe, M, Sato, S, Yamamoto, M, Kaisho, T, Hemmi, H

Science 2003
17676477 Molecular cloning and expression analysis of chicken MyD88 and TRIF genes

Brisbin, JT, Lambourne, MD, Sharif, S, Mayameei, A, Sarson, AJ, Wheaton, S

DNA Seq 2007
12539043 TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

Matsumoto, M, Oshiumi, H, Funami, K, Akazawa, T, Seya, T

Nat Immunol 2003
Inferred From
Cite Us!