Embryonic fibroblast cells from TBK1-deficient mice show decreased IRF3 activation and IFN induction by poly IC, while IKKi-deficient cells show normal IRF3 activation. However, residual activation of IRF3 in TBK1-deficient cells is totally abolished in TBK1 and IKKi double-deficient cells, indicating that the functions of TBK1 and IKKi are redundant in fibroblast cells.[Hemmi et al 2004].
It was also reported that IKKi directly phophorylates signal transducer and activator of transcription 1 (STAT1) [Tenoever et al 2007].
Chicken IKKi shows 68% and 62% identity to the human IKKi and human TBK1 respectively.
Takeuchi, O, Hoshino, K, Sanjo, H, Takeda, K, Sato, S, Yamamoto, M, Kaisho, T, Kawai, T, Hemmi, H
Garcia-Sastre, A, Chua, MA, Ng, SL, McWhirter, SM, Tenoever, BR, Maniatis, T
© 2023 Reactome
