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NFkB and MAPK activation mediated by TRAF6
Stable Identifier
R-GGA-433822
Type
Pathway
Species
Gallus gallus
Related Species
Salmonella typhimurium
ReviewStatus
5/5
Locations in the PathwayBrowser
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Innate Immune System (Gallus gallus)
Toll-like receptors (TLR) cascades (Gallus gallus)
TLR15 cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
TLR2 subfamily cascade (Gallus gallus)
MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
TLR4 cascade (Gallus gallus)
MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
TLR5 cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
NFkB and MAPK activation mediated by TRAF6 (Gallus gallus)
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Treatment of chicken heterophiles with either flagellin or lipopolysaccharide induces the expression and secretion of pro-inflammatory cytokines and chemokines (IL-6, IL-18, IL-1 beta, CXCLi2) through activation of transcription factors NFkB and AP-1.
Literature References
PubMed ID
Title
Journal
Year
18669607
Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways
Kogut, MH
,
Genovese, KJ
,
Kaiser, P
,
He, H
Innate Immun
2008
17045653
Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1
Kogut, MH
,
Genovese, KJ
,
He, H
Mol Immunol
2007
Participants
Events
TRAF6 binds to p-IRAK2 complexed with activated TLR
(Gallus gallus)
p-IRAK2- TRAF6 dissociates from the activated chTLR complex
(Gallus gallus)
TRAF6 binding to activated IRAK2 stimulates its oligomerization
(Gallus gallus)
Auto ubiquitination of oligo TRAF6 bound to p-IRAK2
(Gallus gallus)
Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6
(Gallus gallus)
pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex
(Gallus gallus)
Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1
(Gallus gallus)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
(Gallus gallus)
MAPK activation in TLR cascade
(Gallus gallus)
Participates
as an event of
MyD88 cascade initiated on plasma membrane (Gallus gallus)
MyD88:TIRAP-dependent cascade initiated on plasma membrane (Gallus gallus)
Authored
Shamovsky, V (2009-08-27)
Reviewed
D'Eustachio, P (2010-10-16)
Created
Shamovsky, V (2009-08-27)
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