Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1

Stable Identifier
Reaction [omitted]
Gallus gallus
Related Species
Infectious bronchitis virus
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TRAF6 generates unanchored Lys63-linked polyubiquitin chains that bind to the regulatory subunits of the TAK1 (TAB2 or TAB3), leading to the activation of TAK1[Xia et al. 2009].

Literature References
PubMed ID Title Journal Year
14633987 Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling

Shibuya, H, Gaynor, RB, Ninomiya-Tsuji, J, Takaesu, G, Ishitani, T, Matsumoto, K

EMBO J 2003
17496917 Ubiquitin-mediated activation of TAK1 and IKK

Xu, M, Adhikari, A, Chen, ZJ

Oncogene 2007
15836773 TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway

Kishida, S, Sanjo, H, Ninomiya-Tsuji, J, Akira, S, Matsumoto, K

Genes Cells 2005
19675569 Direct activation of protein kinases by unanchored polyubiquitin chains

Adhikari, A, Zeng, W, Chen, ZJ, Pineda, G, Sun, L, Chen, X, Jiang, X, Xia, ZP

Nature 2009
Event Information
Catalyst Activity

ubiquitin-protein transferase activity of viral ds RNA : TLR3 : TICAM1 : pUb-TRAF6 [endosome membrane]

Inferred From
Cite Us!