TRAF6 recruits TAK1 kinase complex

Stable Identifier
R-GGA-433950
Type
Reaction [binding]
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
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Polyubiquitinated TRAF6 activates TAK1 by binding to the ubiquitin receptor TAB2 (also known as MAP3K7IP2). This binding leads to autophosphorylation and activation of TAK1.

Literature References
PubMed ID Title Journal Year
19675569 Direct activation of protein kinases by unanchored polyubiquitin chains

Xia, ZP, Sun, L, Chen, X, Pineda, G, Jiang, X, Adhikari, A, Zeng, W, Chen, ZJ

Nature 2009
17496917 Ubiquitin-mediated activation of TAK1 and IKK

Adhikari, A, Xu, M, Chen, ZJ

Oncogene 2007
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