Dimerized Phospho-IRF3 is Transported To The Nucleus

Stable Identifier
R-GGA-433967
Type
Reaction
Species
Gallus gallus
Compartment
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Summation

Phosphorylation and dimerization of IRF3 results in the cytoplasm-to-nucleus translocation of IRF-3, DNA binding, and increased transcriptional activation.

Literature References
PubMed ID Title Journal Year
12692549 IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway Nat Immunol 2003
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