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Dimerized Phospho-IRF3 is Transported To The Nucleus

Stable Identifier
R-GGA-433967
Type
Reaction
Species
Gallus gallus
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylation and dimerization of IRF3 results in the cytoplasm-to-nucleus translocation of IRF-3, DNA binding, and increased transcriptional activation.

Literature References
PubMed ID Title Journal Year
12692549 IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway Nat Immunol 2003
Participants
Participant Of
Inferred From