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LPS binding to CD14 co-receptor
Stable Identifier
R-GGA-434003
Type
Reaction [transition]
Species
Gallus gallus
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Innate Immune System (Gallus gallus)
Toll-like receptors (TLR) cascades (Gallus gallus)
TLR4 cascade (Gallus gallus)
LPS binding to CD14 co-receptor (Gallus gallus)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Chicken CD14 was reported to be involved in chicken TLR4 activation (Kogut et al 2005). It was cloned from chicken bone marrow cell RNA and is expressed in most lymphoid and non-lymphoid tissues (Wu Z et al 2009). Its cDNA encodes an open reading frame of 465 amino acids, which shares 31-34% identity to mouse, bovine and human CD14 amino acid sequences.
Literature References
PubMed ID
Title
Journal
Year
18761368
Chicken CD14, unlike mammalian CD14, is trans-membrane rather than GPI-anchored
Hu, T
,
Rothwell, L
,
Wu, Z
,
Kaiser, P
Dev Comp Immunol
2009
Participants
Input
CD14 co-receptor [plasma membrane]
(Gallus gallus)
LBP : LPS complex [extracellular region]
(Gallus gallus)
Output
CD14 :LPS complex [plasma membrane]
(Gallus gallus)
Lipopolysaccharide binding protein [extracellular region]
(Gallus gallus)
Participates
as an event of
TLR4 cascade (Gallus gallus)
Authored
Shamovsky, V (2009-08-27)
Reviewed
D'Eustachio, P (2010-10-16)
Created
Shamovsky, V (2009-08-27)
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